Fasting-mimicking diet remodels gut microbiota and suppresses colorectal cancer progression.

IF 7.8 1区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

npj Biofilms and Microbiomes Pub Date : 2024-06-25 DOI:10.1038/s41522-024-00520-w

Man Luo, Qingyi Wang, Yong Sun, Yao Jiang, Qiwen Wang, Yanrou Gu, Zhefang Hu, Qianyi Chen, Jilei Xu, Shujie Chen, Tongyao Hou, Lijun Feng

{"title":"Fasting-mimicking diet remodels gut microbiota and suppresses colorectal cancer progression.","authors":"Man Luo, Qingyi Wang, Yong Sun, Yao Jiang, Qiwen Wang, Yanrou Gu, Zhefang Hu, Qianyi Chen, Jilei Xu, Shujie Chen, Tongyao Hou, Lijun Feng","doi":"10.1038/s41522-024-00520-w","DOIUrl":null,"url":null,"abstract":"The progression of colorectal cancer is closely associated with diet. Fasting-mimicking diet (FMD) is a promising type of dietary intervention that have beneficial effects in the prevention and treatment of various cancers. We investigated the therapeutic effect of 4-day FMD against colorectal cancer in mice through immune cell analysis, microbiota composition analysis and anti-PD-1 treatment. These FMD cycles effectively suppressed colorectal cancer growth, reduced cell proliferation and angiogenesis, increased tumor-infiltration lymphocytes especially CD8+T cells. FMD stimulated protective gut microbiota, especially Lactobacillus. Supplementation of Lactobacillus johnsonii induced similar results as FMD intervention, which also suppressed tumor growth and increased CD45+ and CD8+ T cells. Additionally, FMD synthesizing with anti-PD-1 therapy effectively inhibited CRC progression. These findings suggest that Lactobacillus. johnsonii is necessary for the anticancer process of FMD in CRC. FMD through its effects on both gut microbiota and immune system, effectively suppressed colorectal cancer progression in mouse model.","PeriodicalId":19370,"journal":{"name":"npj Biofilms and Microbiomes","volume":"10 1","pages":"53"},"PeriodicalIF":7.8000,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11199600/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"npj Biofilms and Microbiomes","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1038/s41522-024-00520-w","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

The progression of colorectal cancer is closely associated with diet. Fasting-mimicking diet (FMD) is a promising type of dietary intervention that have beneficial effects in the prevention and treatment of various cancers. We investigated the therapeutic effect of 4-day FMD against colorectal cancer in mice through immune cell analysis, microbiota composition analysis and anti-PD-1 treatment. These FMD cycles effectively suppressed colorectal cancer growth, reduced cell proliferation and angiogenesis, increased tumor-infiltration lymphocytes especially CD8⁺T cells. FMD stimulated protective gut microbiota, especially Lactobacillus. Supplementation of Lactobacillus johnsonii induced similar results as FMD intervention, which also suppressed tumor growth and increased CD45⁺ and CD8⁺ T cells. Additionally, FMD synthesizing with anti-PD-1 therapy effectively inhibited CRC progression. These findings suggest that Lactobacillus. johnsonii is necessary for the anticancer process of FMD in CRC. FMD through its effects on both gut microbiota and immune system, effectively suppressed colorectal cancer progression in mouse model.

Abstract Image

查看原文本刊更多论文

模拟空腹饮食可重塑肠道微生物群并抑制结直肠癌的发展。

大肠癌的进展与饮食密切相关。空腹模拟饮食（FMD）是一种很有前景的饮食干预方法，对预防和治疗各种癌症有好处。我们通过免疫细胞分析、微生物群组成分析和抗 PD-1 治疗，研究了 4 天 FMD 对小鼠结直肠癌的治疗效果。这些 FMD 循环有效抑制了结直肠癌的生长，减少了细胞增殖和血管生成，增加了肿瘤浸润淋巴细胞，尤其是 CD8+T 细胞。FMD 可刺激保护性肠道微生物群，尤其是乳酸杆菌。补充约翰逊乳杆菌与 FMD 的干预效果相似，也能抑制肿瘤生长，增加 CD45+ 和 CD8+ T 细胞。此外，FMD与抗PD-1疗法的合成能有效抑制CRC的进展。这些研究结果表明，约翰逊乳杆菌对 FMD 在 CRC 中的抗癌过程是必要的。FMD通过对肠道微生物群和免疫系统的影响，有效抑制了小鼠模型中结直肠癌的进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

npj Biofilms and Microbiomes Immunology and Microbiology-Microbiology

CiteScore

12.10

自引率

3.30%

发文量

审稿时长

9 weeks

期刊介绍： npj Biofilms and Microbiomes is a comprehensive platform that promotes research on biofilms and microbiomes across various scientific disciplines. The journal facilitates cross-disciplinary discussions to enhance our understanding of the biology, ecology, and communal functions of biofilms, populations, and communities. It also focuses on applications in the medical, environmental, and engineering domains. The scope of the journal encompasses all aspects of the field, ranging from cell-cell communication and single cell interactions to the microbiomes of humans, animals, plants, and natural and built environments. The journal also welcomes research on the virome, phageome, mycome, and fungome. It publishes both applied science and theoretical work. As an open access and interdisciplinary journal, its primary goal is to publish significant scientific advancements in microbial biofilms and microbiomes. The journal enables discussions that span multiple disciplines and contributes to our understanding of the social behavior of microbial biofilm populations and communities, and their impact on life, human health, and the environment.