Revitalizing the Aging Immune System Through Selective Stem Cell Targeting.

IF 1.2 4区医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Cellular reprogramming Pub Date : 2024-06-01 DOI:10.1089/cell.2024.0029

Anna Konturek-Ciesla, David Bryder

引用次数: 0

Abstract

The interplay between aging and immune system deterioration presents a formidable challenge to human health, especially in the context of a globally aging population. Aging is associated with a decline in the body's ability to combat infections and an increased risk of various diseases, underlining the importance of rejuvenating the immune system as a strategy for promoting healthier aging. In issue 628 of Nature (2024), Ross et al. present a compelling study that introduces a novel strategy for rejuvenating the aged immune system (Ross et al., 2024). By using antibodies to selectively eliminate "aberrant" hematopoietic stem cells (HSCs), this research opens new avenues for addressing age-related immune deterioration.

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通过选择性干细胞靶向激活老化的免疫系统

衰老与免疫系统退化之间的相互作用给人类健康带来了严峻的挑战，尤其是在全球人口老龄化的背景下。衰老与机体抗感染能力下降和罹患各种疾病的风险增加有关，这凸显了振兴免疫系统作为促进健康老龄化战略的重要性。在第 628 期《自然》杂志（2024 年）上，罗斯等人发表了一项引人注目的研究，介绍了一种使衰老的免疫系统恢复活力的新策略（罗斯等人，2024 年）。这项研究利用抗体选择性地消除 "异常 "造血干细胞（HSCs），为解决与年龄有关的免疫衰退问题开辟了新途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular reprogramming CELL & TISSUE ENGINEERING-BIOTECHNOLOGY & APPLIED MICROBIOLOGY

CiteScore

2.50

自引率

6.20%

发文量

审稿时长

3 months

期刊介绍： Cellular Reprogramming is the premier journal dedicated to providing new insights on the etiology, development, and potential treatment of various diseases through reprogramming cellular mechanisms. The Journal delivers information on cutting-edge techniques and the latest high-quality research and discoveries that are transforming biomedical research. Cellular Reprogramming coverage includes: Somatic cell nuclear transfer and reprogramming in early embryos Embryonic stem cells Nuclear transfer stem cells (stem cells derived from nuclear transfer embryos) Generation of induced pluripotent stem (iPS) cells and/or potential for cell-based therapies Epigenetics Adult stem cells and pluripotency.