Sex disparity in stroke risk among patients with insomnia: a 19-year prospective cohort study.

IF 3.5 3区医学 Q1 CLINICAL NEUROLOGY

Journal of Clinical Sleep Medicine Pub Date : 2024-10-01 DOI:10.5664/jcsm.11268

Eujene Jung, Dong Ki Kim, Sun Young Lee, Hyun Ho Ryu

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引用次数: 0

Abstract

Study objectives: Considering the increased prevalence and more severe manifestations of insomnia among females along with established sex differences in ischemic stroke (IS) occurrence, this research aimed to examine the potential effects of the interaction between insomnia and sex on the incidence and outcome of IS.

Methods: We used data from the Korean Genome and Epidemiology Study. The main exposure variables were insomnia history and sex. The main outcome was the occurrence of IS observed in biennial follow-up surveys. Cox proportional regression analysis was performed to estimate the effects of insomnia and sex on IS incidence. We also conducted interaction analysis to investigate the interaction effects between insomnia and sex on IS incidence.

Results: During 19 years of follow-up involving 8,933 individuals, we documented 370 cases of new-onset stroke (2.88 cases per 1,000 person-years). Cox proportional regression analysis showed that insomnia and female sex did not increase the risk of IS (hazard ratio: 1.13 [95% confidence interval: 0.86-1.51] and hazard ratio: 0.86 [95% confidence interval: 0.63-1.17], respectively). Interaction analysis demonstrated that stroke risk was increased only among females with insomnia (hazard ratio: 1.34 [95% confidence interval: 1.05-1.80]) compared with those without insomnia.

Conclusions: Our study highlights the significance of considering sex-specific factors when evaluating the relationship between insomnia and IS risk, particularly emphasizing the unique role of insomnia in IS risk among females.

Citation: Jung E, Kim DK, Lee SY, Ryu HH. Sex disparity in stroke risk among patients with insomnia: a 19-year prospective cohort study. J Clin Sleep Med. 2024;20(10):1669-1674.

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失眠患者中风风险的性别差异：一项为期 19 年的前瞻性队列研究。

研究目的考虑到女性失眠症的发病率更高、表现更严重，以及缺血性脑卒中（IS）发生的性别差异，本研究旨在探讨失眠症与性别之间的相互作用对 IS 发病率和预后的潜在影响：我们使用了韩国基因组与流行病学研究（KoGES）的数据。主要暴露变量为失眠史和性别。主要结果是两年一次的随访调查中观察到的IS发生率。我们进行了 Cox 比例回归分析，以估计失眠和性别对 IS 发生率的影响。我们还进行了交互分析，研究失眠和性别对IS发生率的交互影响：结果：在对 8,933 人进行的 19 年随访中，我们记录了 370 例新发中风病例（每千人年 2.88 例）。Cox 比例回归分析显示，失眠和女性性别不会增加 IS 风险（HR：1.13 [95% CI：0.86-1.51] 和 HR：0.86 [95% CI：0.63-1.17]）。交互分析表明，与没有失眠的女性相比，只有失眠的女性中风风险增加（HR：1.34 [95%：1.05-1.80]）：我们的研究强调了在评估失眠与 IS 风险之间的关系时考虑性别特异性因素的重要性，尤其强调了失眠在女性 IS 风险中的独特作用。

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来源期刊

Journal of Clinical Sleep Medicine CLINICAL NEUROLOGY-

CiteScore

6.20

自引率

7.00%

发文量

321

审稿时长

1 months

期刊介绍： Journal of Clinical Sleep Medicine focuses on clinical sleep medicine. Its emphasis is publication of papers with direct applicability and/or relevance to the clinical practice of sleep medicine. This includes clinical trials, clinical reviews, clinical commentary and debate, medical economic/practice perspectives, case series and novel/interesting case reports. In addition, the journal will publish proceedings from conferences, workshops and symposia sponsored by the American Academy of Sleep Medicine or other organizations related to improving the practice of sleep medicine.