Implementation of effective strategies to prevent Candida auris transmission in a Quaternary Care Center, Riyadh, Saudi Arabia.

IF 1.9 4区医学 Q3 INFECTIOUS DISEASES

Journal of Chemotherapy Pub Date : 2024-06-24 DOI:10.1080/1120009X.2024.2370207

Nazia Khanum, Sarah H Alfaraj, Khulood Naser Alboqmy, Faleh Alshakrah, Nadeem Gul Dar, Hassan Abdallah, Deva Kumar, Mona Alsalam, Abdullah Hussein Mohammed Abu-Salah, Antisar Abdulrahman Alsunaid, Rashed Abdulaziz Rashed Alhamed, Prince Kochummen Cherian, Ohoud Mohammed Alharbi, Nada Yousef Alhemaid, Mary Ann M Mamayabay, Ziad A Memish

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引用次数: 0

Abstract

This study outlines the results of an investigation of a large C. auris outbreak at King Saud Medical City (KSMC), a quaternary hospital in Saudi Arabia. We identified 122 cases of C. auris (colonization, 74; infection, 48) from June 2021 to June 2022. The mean patient age was 48.4 years, and the median duration of stay before diagnosis was 32.7 days. A significant proportion of patients (87.70%) were diagnosed with C. auris more than 3 days after admission to KSMC. The source of exposure was either nosocomial (from KSMC, 28.68%; from other hospitals, 16.39%) or unknown (54.91%). The hospitalization mortality rate was 45.90%. This report highlights the challenges in investigating and managing C. auris outbreaks, emphasizing the need for a comprehensive approach incorporating strategies for screening and early identification, effective environmental cleaning, and the implementation of stringent infection control measures such as hand hygiene, isolation of patient, standard and contact precaution and decolonization.

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在沙特阿拉伯利雅得的一家四级护理中心实施预防念珠菌传播的有效策略。

本研究概述了沙特阿拉伯一家四级医院沙特国王医疗城（King Saud Medical City，KSMC）爆发的大规模阴沟杆菌疫情的调查结果。我们在 2021 年 6 月至 2022 年 6 月期间发现了 122 例肠炎双球菌病例（定植 74 例；感染 48 例）。患者平均年龄为 48.4 岁，确诊前住院时间中位数为 32.7 天。相当大比例的患者（87.70%）在入住 KSMC 超过 3 天后被确诊为阿氏杆菌感染。感染来源为医院内（28.68%来自KSMC，16.39%来自其他医院）或未知（54.91%）。住院死亡率为 45.90%。本报告突出强调了调查和处理法氏囊病爆发所面临的挑战，强调有必要采取综合方法，包括筛查和早期识别策略、有效的环境清洁以及实施严格的感染控制措施，如手部卫生、隔离病人、标准和接触预防措施以及去菌落治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Chemotherapy 医学-药学

CiteScore

3.70

自引率

0.00%

发文量

144

审稿时长

6-12 weeks

期刊介绍： The Journal of Chemotherapy is an international multidisciplinary journal committed to the rapid publication of high quality, peer-reviewed, original research on all aspects of antimicrobial and antitumor chemotherapy. The Journal publishes original experimental and clinical research articles, state-of-the-art reviews, brief communications and letters on all aspects of chemotherapy, providing coverage of the pathogenesis, diagnosis, treatment, and control of infection, as well as the use of anticancer and immunomodulating drugs. Specific areas of focus include, but are not limited to: · Antibacterial, antiviral, antifungal, antiparasitic, and antiprotozoal agents; · Anticancer classical and targeted chemotherapeutic agents, biological agents, hormonal drugs, immunomodulatory drugs, cell therapy and gene therapy; · Pharmacokinetic and pharmacodynamic properties of antimicrobial and anticancer agents; · The efficacy, safety and toxicology profiles of antimicrobial and anticancer drugs; · Drug interactions in single or combined applications; · Drug resistance to antimicrobial and anticancer drugs; · Research and development of novel antimicrobial and anticancer drugs, including preclinical, translational and clinical research; · Biomarkers of sensitivity and/or resistance for antimicrobial and anticancer drugs; · Pharmacogenetics and pharmacogenomics; · Precision medicine in infectious disease therapy and in cancer therapy; · Pharmacoeconomics of antimicrobial and anticancer therapies and the implications to patients, health services, and the pharmaceutical industry.