Utilization and efficacy of platelet-rich plasma and platelet-rich fibrin in otolaryngology: a systematic evidence-based review.

IF 1.9 3区医学 Q2 OTORHINOLARYNGOLOGY

European Archives of Oto-Rhino-Laryngology Pub Date : 2024-10-01 Epub Date: 2024-06-24 DOI:10.1007/s00405-024-08763-1

Alireza Sharifi, Ali Kouhi, Zara M Patel

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引用次数: 0

Abstract

Purpose: To explore utilization and efficacy of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in different sub-specialties of otolaryngology.

Methods: A systematic search was performed using Cochrane Central Register of Controlled Trials, PubMed, EMBASE, Medline, Clinicaltrials.gov, Scopus, and Google Scholar up to March 2024. English language randomized controlled trials with original data evaluating the use of PRP and PRF in various surgical and non-surgical procedures related to otolaryngologic sub-specialties. Dataset was limited to randomized controlled trials (RCTs) to have the best quality of evidence and possible recommendation.

Results: Our database search resulted in 591 manuscripts. Four hundred twenty-six studies were primarily excluded after reviewing the title and abstract. The remaining 165 articles were studied completely, and 51 articles met the inclusion criteria. All the studies were RCTs and dated from 2001 to 2024. They included 19 studies related to otology, 10 studies related to rhinology, 7 studies related to facial plastic surgery, 6 studies related to head and neck surgery, 3 studies related to general otolaryngology, 3 studies related to pediatrics, 2 studies related to laryngology, and 1 study related to sleep medicine.

Conclusion: PRP and PRF are safe, easy to use, and potentially effective treatment options for multiple otolaryngology pathologies. As an autologous material, there is no risk of immune reaction, and thus has been selected as a viable treatment option by many otolaryngologists. Larger studies would be helpful to confirm efficacy and allow for optimized patient selection for this treatment option.

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富血小板血浆和富血小板纤维蛋白在耳鼻喉科中的应用和疗效：基于证据的系统性综述。

目的：探讨富血小板血浆（PRP）和富血小板纤维蛋白（PRF）在耳鼻喉科不同亚专科中的应用和疗效：方法：使用 Cochrane Central Register of Controlled Trials、PubMed、EMBASE、Medline、Clinicaltrials.gov、Scopus 和 Google Scholar（截至 2024 年 3 月）进行系统检索。包含原始数据的英文随机对照试验，这些试验评估了 PRP 和 PRF 在与耳鼻喉亚专科相关的各种手术和非手术疗法中的应用。数据集仅限于随机对照试验（RCT），以获得最佳证据质量和可能的推荐：我们在数据库中搜索到 591 篇手稿。在审查了标题和摘要后，主要排除了 426 项研究。对剩余的 165 篇文章进行了全面研究，其中 51 篇符合纳入标准。所有研究均为 RCT，研究时间为 2001 年至 2024 年。其中包括19项与耳科相关的研究、10项与鼻科相关的研究、7项与面部整形相关的研究、6项与头颈外科相关的研究、3项与普通耳鼻喉科相关的研究、3项与儿科相关的研究、2项与喉科相关的研究以及1项与睡眠医学相关的研究：结论：PRP 和 PRF 是治疗多种耳鼻喉科病症的安全、易用且潜在有效的方法。由于是自体材料，没有免疫反应的风险，因此被许多耳鼻喉科医生选为可行的治疗方案。更大规模的研究将有助于确认疗效，并为这种治疗方法优化患者选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Archives of Oto-Rhino-Laryngology 医学-耳鼻喉科学

CiteScore

5.30

自引率

7.70%

发文量

537

审稿时长

2-4 weeks

期刊介绍： Official Journal of European Union of Medical Specialists – ORL Section and Board Official Journal of Confederation of European Oto-Rhino-Laryngology Head and Neck Surgery "European Archives of Oto-Rhino-Laryngology" publishes original clinical reports and clinically relevant experimental studies, as well as short communications presenting new results of special interest. With peer review by a respected international editorial board and prompt English-language publication, the journal provides rapid dissemination of information by authors from around the world. This particular feature makes it the journal of choice for readers who want to be informed about the continuing state of the art concerning basic sciences and the diagnosis and management of diseases of the head and neck on an international level. European Archives of Oto-Rhino-Laryngology was founded in 1864 as "Archiv für Ohrenheilkunde" by A. von Tröltsch, A. Politzer and H. Schwartze.