Treatment options in the advanced and recurrent setting for endometrial cancer: an update.

IF 2.9 3区医学 Q2 ONCOLOGY

Expert Review of Anticancer Therapy Pub Date : 2024-08-01 Epub Date: 2024-06-24 DOI:10.1080/14737140.2024.2370377

Alex Andrea Francoeur, Virginia Fontenont, Krishnansu Sujata Tewari

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引用次数: 0

Abstract

Introduction: Uterine cancer is the most common gynecologic malignancy in women and is projected to surpass ovarian cancer as the deadliest gynecologic malignancy in the United States in 2024. Additionally, rates of advanced and high-risk uterine cancer have been on the rise in the United States, demonstrating a need for innovation in treatment options. There have been multiple recent trials investigating the incorporation of novel agents in the treatment of advanced and recurrent endometrial cancer.

Areas covered: This article will discuss the current landscape of the treatment of advanced and recurrent endometrial cancer, focusing on recent phase III trials published or presented on with the incorporation of immunotherapy and other novel therapeutics while also reviewing promising phase I and II trials in the field. Clinical trials were identified via clinicaltrials.gov and a PubMed literature search was performed (initially February 2024, updated May 2024).

Expert opinion: The treatment field is promising for patients as many of these trials appear to offer progression free and overall survival benefits in a disease with a historically poor prognosis. Molecular profiling of endometrial cancer will be the backbone of treatment paradigms in the future.

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子宫内膜癌晚期和复发的治疗方案：最新进展。

导言：子宫癌是女性最常见的妇科恶性肿瘤，预计 2024 年将超过卵巢癌成为美国最致命的妇科恶性肿瘤。此外，在美国，晚期和高危子宫癌的发病率一直在上升，这表明需要创新治疗方案。最近有多项试验正在研究将新型药物用于晚期和复发性子宫内膜癌的治疗：本文将讨论晚期和复发性子宫内膜癌治疗的现状，重点关注最近发表或介绍的结合免疫疗法和其他新型疗法的 III 期试验，同时还将回顾该领域前景看好的 I 期和 II 期试验。临床试验通过 clinicaltrials.gov 确定，并进行了 PubMed 文献检索（最初于 2024 年 2 月进行，2024 年 5 月更新）：专家观点：对于患者来说，该治疗领域前景广阔，因为其中许多试验似乎都能为这种预后历来较差的疾病带来无进展生存期和总生存期的益处。子宫内膜癌的分子图谱分析将成为未来治疗模式的支柱。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Anticancer Therapy 医学-肿瘤学

CiteScore

5.10

自引率

3.00%

发文量

100

审稿时长

4-8 weeks

期刊介绍： Expert Review of Anticancer Therapy (ISSN 1473-7140) provides expert appraisal and commentary on the major trends in cancer care and highlights the performance of new therapeutic and diagnostic approaches. Coverage includes tumor management, novel medicines, anticancer agents and chemotherapy, biological therapy, cancer vaccines, therapeutic indications, biomarkers and diagnostics, and treatment guidelines. All articles are subject to rigorous peer-review, and the journal makes an essential contribution to decision-making in cancer care. Comprehensive coverage in each review is complemented by the unique Expert Review format and includes the following sections: Expert Opinion - a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results Article Highlights – an executive summary of the author’s most critical points.