Fusobacterium Detected in Barrett's Esophagus and Esophageal Adenocarcinoma Tissues.

IF 1.8 4区医学 Q3 ONCOLOGY

Cancer Investigation Pub Date : 2024-07-01 Epub Date: 2024-06-24 DOI:10.1080/07357907.2024.2359980

Tomomitsu Tahara, Takuya Shijimaya, Jumpei Yamazaki, Sanshiro Kobayashi, Anna Horitani, Yasushi Matsumoto, Naohiro Nakamura, Takashi Okazaki, Yu Takahashi, Takashi Tomiyama, Yusuke Honzawa, Norimasa Fukata, Toshiro Fukui, Makoto Naganuma

引用次数: 0

Abstract

We examined Fusobacterium nucreatum (F. nucleatum) and whole Fusobacterium species (Pan-fusobacterium) in non-neoplastic Barrett's esophagus (BE) from patients without cancer (n = 67; N group), with esophageal adenocarcinoma (EAC) (n = 27) and EAC tissue (n = 22). F. nucleatum was only detectable in 22.7% of EAC tissue. Pan-fusobacterium was enriched in EAC tissue and associated with aggressive clinicopathological features. Amount of Pan-fusobacterium in non-neoplastic BE was correlated with presence of hital hernia and telomere shortening. The result suggested potential association of Fusobacterium species in EAC and BE, featuring clinicpathological and molecular features.

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在巴雷特食管和食管腺癌组织中检测到镰刀菌

我们检测了非肿瘤性巴雷特食管（BE）患者（n = 67；N 组）、食管腺癌（EAC）患者（n = 27）和 EAC 组织（n = 22）中的核仁镰刀菌（F. nucleatum）和整个镰刀菌种（Pan-fusobacterium）。仅在 22.7% 的 EAC 组织中检测到核酸酵母菌。泛螺旋体在EAC组织中富集，并与侵袭性临床病理特征相关。非肿瘤性 BE 中的泛镰状杆菌数量与疝和端粒缩短相关。结果表明，EAC和BE中的镰刀菌可能与临床病理和分子特征有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Investigation 医学-肿瘤学

CiteScore

3.80

自引率

4.20%

发文量

审稿时长

8.5 months

期刊介绍： Cancer Investigation is one of the most highly regarded and recognized journals in the field of basic and clinical oncology. It is designed to give physicians a comprehensive resource on the current state of progress in the cancer field as well as a broad background of reliable information necessary for effective decision making. In addition to presenting original papers of fundamental significance, it also publishes reviews, essays, specialized presentations of controversies, considerations of new technologies and their applications to specific laboratory problems, discussions of public issues, miniseries on major topics, new and experimental drugs and therapies, and an innovative letters to the editor section. One of the unique features of the journal is its departmentalized editorial sections reporting on more than 30 subject categories covering the broad spectrum of specialized areas that together comprise the field of oncology. Edited by leading physicians and research scientists, these sections make Cancer Investigation the prime resource for clinicians seeking to make sense of the sometimes-overwhelming amount of information available throughout the field. In addition to its peer-reviewed clinical research, the journal also features translational studies that bridge the gap between the laboratory and the clinic.