The involvement of signaling pathways in the pathogenesis of osteoarthritis: An update

IF 5.9 1区医学 Q1 ORTHOPEDICS

Journal of Orthopaedic Translation Pub Date : 2024-06-22 DOI:10.1016/j.jot.2024.06.002

Antonietta Fazio , Alberto Di Martino , Matteo Brunello , Francesco Traina , Maria Vittoria Marvi , Antonio Mazzotti , Cesare Faldini , Lucia Manzoli , Camilla Evangelisti , Stefano Ratti

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引用次数: 0

Abstract

Osteoarthritis (OA) is one of the most common disabling pathologies, characterized by joint pain and reduced function, significantly worsening the quality of life. Even if important progresses have been made in OA research, little is yet known about the precise cellular and molecular mechanisms underlying OA. Understanding dysregulated signaling networks and their crosstalk in OA may offer a strong opportunity for the development of combined targeted therapies. Hence, this review highlights the recent findings on the main pathways involved in OA development, including Wnt, Notch, Hedgehog, MAPK, AMPK, and JAK/STAT, providing insights on current targeted therapies in OA patients’ management.

The translational potential of this article

The identification of key signaling pathways involved in OA development and the investigation of their signaling crosstalk could pave the way for more effective treatments and improved management of OA patients in the future.

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信号通路参与骨关节炎的发病机制：最新进展

骨关节炎（OA）是最常见的致残性疾病之一，以关节疼痛和功能减退为特征，严重影响生活质量。尽管骨关节炎研究取得了重大进展，但人们对骨关节炎的确切细胞和分子机制仍然知之甚少。了解 OA 中失调的信号传导网络及其相互协作可能会为开发联合靶向疗法提供良机。因此，这篇综述重点介绍了有关参与 OA 发生的主要通路（包括 Wnt、Notch、Hedgehog、MAPK、AMPK 和 JAK/STAT）的最新研究成果，为当前治疗 OA 患者的靶向疗法提供了启示。本文的转化潜力识别参与 OA 发生的关键信号通路并研究它们之间的信号串扰，可为未来更有效的治疗和改善 OA 患者的管理铺平道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Orthopaedic Translation Medicine-Orthopedics and Sports Medicine

CiteScore

11.80

自引率

13.60%

发文量

审稿时长

29 days

期刊介绍： The Journal of Orthopaedic Translation (JOT) is the official peer-reviewed, open access journal of the Chinese Speaking Orthopaedic Society (CSOS) and the International Chinese Musculoskeletal Research Society (ICMRS). It is published quarterly, in January, April, July and October, by Elsevier.