Studies on the effect of curcumin and quercetin in the liver of male albino rats exposed to gamma irradiation.

IF 2.1 4区 生物学 Q4 CELL BIOLOGY
Histochemistry and Cell Biology Pub Date : 2024-10-01 Epub Date: 2024-06-24 DOI:10.1007/s00418-024-02300-1
Amr M Abd El-Hady, Rady M Azzoz, Saeed M Soliman, Ibrahim Y Abdelrahman, Wafaa M Khalil, Said A Ali
{"title":"Studies on the effect of curcumin and quercetin in the liver of male albino rats exposed to gamma irradiation.","authors":"Amr M Abd El-Hady, Rady M Azzoz, Saeed M Soliman, Ibrahim Y Abdelrahman, Wafaa M Khalil, Said A Ali","doi":"10.1007/s00418-024-02300-1","DOIUrl":null,"url":null,"abstract":"<p><p>Ionizing radiation produces deleterious effects on living organisms. The present investigation has been carried out to study the prophylactic as well as the therapeutic effects of treated rats with quercetin (Quer) and curcumin (Cur), which are two medicinal herbs known for their antioxidant activities against damages induced by whole-body fractionated gamma irradiation. Exposure of rats to whole-body gamma irradiation induced a significant decrease in erythrocyte (RBC), leukocyte (WBCs), platelet count (Plt), hemoglobin concentration (Hb), hematocrit (Hct %), mean erythrocyte hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and mean erythrocyte volume (MCV); a high increase in plasma thiobarbituric acid reactive substances (TBARS); a nonsignificant statistical decrease in the mean value of serum glutathione (GSH); a significant increase in plasma alanine transferase (ALT), aspartate transferase (AST), alkaline phosphates (ALP), serum total protein, serum total cholesterol levels, total triglycerides levels, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) levels; and with marked histological changes and structural changes measured by Fourier transform infrared (FTIR). Applying both quercetin and curcumin pre- and postexposure to gamma radiation revealed a remarkable improvement in all the studied parameters. The cellular damage by gamma radiation is greatly mitigated by the coadministration of curcumin and quercetin before radiation exposure.</p>","PeriodicalId":13107,"journal":{"name":"Histochemistry and Cell Biology","volume":null,"pages":null},"PeriodicalIF":2.1000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11364652/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Histochemistry and Cell Biology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s00418-024-02300-1","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/6/24 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Ionizing radiation produces deleterious effects on living organisms. The present investigation has been carried out to study the prophylactic as well as the therapeutic effects of treated rats with quercetin (Quer) and curcumin (Cur), which are two medicinal herbs known for their antioxidant activities against damages induced by whole-body fractionated gamma irradiation. Exposure of rats to whole-body gamma irradiation induced a significant decrease in erythrocyte (RBC), leukocyte (WBCs), platelet count (Plt), hemoglobin concentration (Hb), hematocrit (Hct %), mean erythrocyte hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and mean erythrocyte volume (MCV); a high increase in plasma thiobarbituric acid reactive substances (TBARS); a nonsignificant statistical decrease in the mean value of serum glutathione (GSH); a significant increase in plasma alanine transferase (ALT), aspartate transferase (AST), alkaline phosphates (ALP), serum total protein, serum total cholesterol levels, total triglycerides levels, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) levels; and with marked histological changes and structural changes measured by Fourier transform infrared (FTIR). Applying both quercetin and curcumin pre- and postexposure to gamma radiation revealed a remarkable improvement in all the studied parameters. The cellular damage by gamma radiation is greatly mitigated by the coadministration of curcumin and quercetin before radiation exposure.

Abstract Image

姜黄素和槲皮素对遭受伽马射线照射的雄性白化大鼠肝脏影响的研究。
电离辐射会对生物体产生有害影响。槲皮素(Quer)和姜黄素(Cur)这两种药草具有抗氧化活性,可预防和治疗全身分段伽马辐照对大鼠造成的损害。对大鼠进行全身伽马辐照会导致红细胞(RBC)、白细胞(WBCs)、血小板计数(Plt)、血红蛋白浓度(Hb)、血细胞比容(Hct %)、平均红细胞血红蛋白(MCH)、平均血红蛋白浓度(MCHC)和平均红细胞容积(MCV)显著下降;血浆中硫代巴比妥酸活性物质(TBARS)显著增加;血清谷胱甘肽(GSH)平均值出现非显著性统计学下降;血浆丙氨酸转移酶(ALT)、天门冬氨酸转移酶(AST)、碱性磷酸酶(ALP)、血清总蛋白、血清总胆固醇水平、总甘油三酯水平、高密度脂蛋白(HDL)和低密度脂蛋白(LDL)水平显著升高;以及傅立叶变换红外光谱(FTIR)测量到的明显组织学变化和结构变化。在伽马射线照射前后使用槲皮素和姜黄素,可以显著改善所有研究参数。在辐照前同时服用姜黄素和槲皮素可大大减轻伽马射线对细胞的损伤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Histochemistry and Cell Biology
Histochemistry and Cell Biology 生物-细胞生物学
CiteScore
4.90
自引率
8.70%
发文量
112
审稿时长
1 months
期刊介绍: Histochemistry and Cell Biology is devoted to the field of molecular histology and cell biology, publishing original articles dealing with the localization and identification of molecular components, metabolic activities and cell biological aspects of cells and tissues. Coverage extends to the development, application, and/or evaluation of methods and probes that can be used in the entire area of histochemistry and cell biology.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信