Meta-analysis of the clinical efficacy of liraglutide in treating type 2 diabetes mellitus complicated with non-alcoholic fatty liver disease.

IF 1.3 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM
Endocrine journal Pub Date : 2024-09-02 Epub Date: 2024-06-22 DOI:10.1507/endocrj.EJ24-0168
Yuan-Yuan Xu, Xu Wang, Yu-Qing She, Jie Liu, Qing Zhang
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Abstract

This study aimed to systematically evaluate the efficacy of liraglutide in treating type 2 diabetes mellitus (T2DM) complicated with non-alcoholic fatty liver disease (NAFLD) by comparing liraglutide with placebo or other drugs (mainly insulin). The PubMed, Web of Science, and National Library of Medicine databases were systematically searched from their inception until December 1, 2023. A meta-analysis was performed using Stata 15.1 software. A total of 12 studies with 13 outcome measures were included. The meta-analysis results revealed that liraglutide significantly reduced body mass index (mean difference [MD] = -1.06, 95%CI: -1.41, -0.70, p < 0.001), triglycerides (MD = -0.35, 95%CI: -0.61, -0.09, p = 0.0009), visceral adipose tissue (MD = -21.06, 95%CI: -34.58, -7.55, p = 0.002), and subcutaneous adipose tissue (MD = -20.53, 95%CI: -29.15, -11.90, p < 0.001) levels in patients with T2DM and NAFLD. Of the 11 studies, 2 reported the occurrence of adverse reactions, which were primarily gastrointestinal. Compared with placebo and other drugs (e.g., insulin), liraglutide may improve glucose metabolism, lipid and liver function parameters, and visceral and subcutaneous fat in patients with T2DM and NAFLD, thus constituting an effective treatment for these patients.

利拉鲁肽治疗并发非酒精性脂肪肝的 2 型糖尿病临床疗效的 Meta 分析。
本研究旨在通过比较利拉鲁肽与安慰剂或其他药物(主要是胰岛素),系统评估利拉鲁肽治疗并发非酒精性脂肪肝的2型糖尿病(T2DM)的疗效。从 PubMed、Web of Science 和美国国家医学图书馆数据库开始系统检索,直至 2023 年 12 月 1 日。使用 Stata 15.1 软件进行了荟萃分析。共纳入了 12 项研究,13 个结果指标。荟萃分析结果显示,利拉鲁肽可显著降低体重指数(平均差 [MD] = -1.06, 95%CI: -1.41, -0.70, p < 0.001)、甘油三酯(MD = -0.35, 95%CI: -0.61, -0.09,p = 0.0009)、内脏脂肪组织(MD = -21.06,95%CI:-34.58,-7.55,p = 0.002)和皮下脂肪组织(MD = -20.53,95%CI:-29.15,-11.90,p < 0.001)水平。在 11 项研究中,有 2 项报告了不良反应的发生,主要是胃肠道反应。与安慰剂和其他药物(如胰岛素)相比,利拉鲁肽可改善T2DM和非酒精性脂肪肝患者的糖代谢、血脂和肝功能指标以及内脏和皮下脂肪,因此是治疗这些患者的有效药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Endocrine journal
Endocrine journal 医学-内分泌学与代谢
CiteScore
4.30
自引率
5.00%
发文量
224
审稿时长
1.5 months
期刊介绍: Endocrine Journal is an open access, peer-reviewed online journal with a long history. This journal publishes peer-reviewed research articles in multifaceted fields of basic, translational and clinical endocrinology. Endocrine Journal provides a chance to exchange your ideas, concepts and scientific observations in any area of recent endocrinology. Manuscripts may be submitted as Original Articles, Notes, Rapid Communications or Review Articles. We have a rapid reviewing and editorial decision system and pay a special attention to our quick, truly scientific and frequently-citable publication. Please go through the link for author guideline.
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