Nucleoid-associated proteins of mycobacteria come with a distinctive flavor

IF 2.6 2区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Microbiology Pub Date : 2024-06-22 DOI:10.1111/mmi.15287

Meghna Santoshi, Priyanka Tare, Valakunja Nagaraja

引用次数: 0

Abstract

In every bacterium, nucleoid-associated proteins (NAPs) play crucial roles in chromosome organization, replication, repair, gene expression, and other DNA transactions. Their central role in controlling the chromatin dynamics and transcription has been well-appreciated in several well-studied organisms. Here, we review the diversity, distribution, structure, and function of NAPs from the genus Mycobacterium. We highlight the progress made in our understanding of the effects of these proteins on various processes and in responding to environmental stimuli and stress of mycobacteria in their free-living as well as during distinctive intracellular lifestyles. We project them as potential drug targets and discuss future studies to bridge the information gap with NAPs from well-studied systems.

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分枝杆菌的核糖体相关蛋白风味独特

在每一种细菌中，核团相关蛋白（NAPs）都在染色体组织、复制、修复、基因表达和其他 DNA 事务中发挥着至关重要的作用。它们在控制染色质动力学和转录中的核心作用在一些研究得很好的生物体中得到了很好的评价。在此，我们回顾了分枝杆菌属中 NAPs 的多样性、分布、结构和功能。我们重点介绍了在了解这些蛋白质对各种过程的影响以及在应对环境刺激和分枝杆菌自由生活和独特的细胞内生活方式的压力方面所取得的进展。我们将这些蛋白预测为潜在的药物靶点，并讨论了未来的研究，以弥合与来自研究充分的系统的 NAPs 之间的信息差距。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Microbiology 生物-生化与分子生物学

CiteScore

7.20

自引率

5.60%

发文量

132

审稿时长

1.7 months

期刊介绍： Molecular Microbiology, the leading primary journal in the microbial sciences, publishes molecular studies of Bacteria, Archaea, eukaryotic microorganisms, and their viruses. Research papers should lead to a deeper understanding of the molecular principles underlying basic physiological processes or mechanisms. Appropriate topics include gene expression and regulation, pathogenicity and virulence, physiology and metabolism, synthesis of macromolecules (proteins, nucleic acids, lipids, polysaccharides, etc), cell biology and subcellular organization, membrane biogenesis and function, traffic and transport, cell-cell communication and signalling pathways, evolution and gene transfer. Articles focused on host responses (cellular or immunological) to pathogens or on microbial ecology should be directed to our sister journals Cellular Microbiology and Environmental Microbiology, respectively.