Is serum BDNF level relıable parameter ın detectıng of dental anxıety before ımpacted thırd molar surgery?

IF 1.8 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Medicina Oral Patologia Oral Y Cirugia Bucal Pub Date : 2024-07-01 DOI:10.4317/medoral.26558

E-C Sıvrıkaya, O Yılmaz, T Tuzuner, Y-T Korkmaz, A Alver, S-M Arıkan, N Kocak, E Sahın

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引用次数: 0

Abstract

Background: Brain-derived neurotrophic factor (BDNF) is a factor that implicate in the pathophysiology and treatment of depression and anxiety. The aim of this study was to determine the relationship between dental anxiety and BDNF serum level through impacted third molar surgery.

Material and methods: In this randomized, double-blind, cross-sectional study, the sample included patients who had been admitted for the impacted third molar extraction under local anesthesia between January to November 2020. The primary predictor variable was serum BDNF level and the second predictor variable was dental anxiety scores before and after operation in patients. The primary outcome variable was the correlation between anxiety scores (APAIS, MDAS, STAI, VAS) and serum BDNF level. The sample included 55 patients (22 Male, 33 Female) aged 18 to 42 (24,2+5,55).

Results: Comparison of pre-operative scores (APAIS, MDAS, STAI, VAS and BDNF) and post-operative scores were statistically significant (P < .05). Post-operatively, MDAS and VAS scores decreased, while BDNF levels and STAI scores increased compared to the preoperative scores. BDNF was not correlated with APAIS, MDAS, STAI, and VAS preoperatively and postoperatively.

Conclusions: There may be a relationship between serum BDNF level and dental anxiety scale, but, no correlation was found between them.

查看原文本刊更多论文

血清 BDNF 水平是否是检测第三磨牙手术前牙齿焦虑症的相关参数？

背景：脑源性神经营养因子（BDNF）是一种与抑郁症和焦虑症的病理生理学和治疗有关的因子。本研究旨在通过影响第三磨牙手术确定牙科焦虑与 BDNF 血清水平之间的关系：在这项随机、双盲、横断面研究中，样本包括 2020 年 1 月至 11 月期间在局部麻醉下接受第三磨牙拔除术的患者。主要预测变量为血清BDNF水平，次要预测变量为患者手术前后的牙科焦虑评分。主要结果变量是焦虑评分（APAIS、MDAS、STAI、VAS）与血清BDNF水平之间的相关性。样本包括 55 名患者（22 名男性，33 名女性），年龄在 18 至 42 岁之间（24,2+5,55）：术前评分（APAIS、MDAS、STAI、VAS 和 BDNF）与术后评分比较有统计学意义（P < .05）。与术前相比，术后 MDAS 和 VAS 评分下降，而 BDNF 水平和 STAI 评分上升。BDNF与APAIS、MDAS、STAI和VAS在术前和术后均无相关性：结论：血清 BDNF 水平与牙科焦虑量表之间可能存在一定关系，但两者之间未发现相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medicina Oral Patologia Oral Y Cirugia Bucal DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

3-8 weeks

期刊介绍： 1. Oral Medicine and Pathology: Clinicopathological as well as medical or surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, as well as orofacial neurological disorders, and systemic conditions with an impact on the oral cavity. 2. Oral Surgery: Surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, teeth, implants, oral surgical procedures. Surgical management of diseases affecting head and neck areas. 3. Medically compromised patients in Dentistry: Articles discussing medical problems in Odontology will also be included, with a special focus on the clinico-odontological management of medically compromised patients, and considerations regarding high-risk or disabled patients. 4. Implantology 5. Periodontology