DNA mismatch repair system expression in salivary gland tumors: A Systematic Review.

IF 1.8 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Medicina Oral Patologia Oral Y Cirugia Bucal Pub Date : 2024-09-01 DOI:10.4317/medoral.26647

G-M-T-T Alves, R-J Severino-Lazo, G-K Amaral-Silva, F-M Silveira, M-D Carvalho

{"title":"DNA mismatch repair system expression in salivary gland tumors: A Systematic Review.","authors":"G-M-T-T Alves, R-J Severino-Lazo, G-K Amaral-Silva, F-M Silveira, M-D Carvalho","doi":"10.4317/medoral.26647","DOIUrl":null,"url":null,"abstract":"Background: The DNA mismatch repair (MMR) system serves as a sophisticated guardian of the precise functioning of the human genome. Dysregulation within this system is linked to the oncogenesis process. Reduced expression of MMR system proteins identified in salivary gland tumors (SGTs) suggests an increased risk of tumoral occurrence. This study aims to analyze the expression of MMR proteins in SGTs and discuss the relevance of this association to the development of these neoplasms.Material and methods: This review was conducted following the PRISMA guidelines and was registered in PROSPERO (CRD42023465590). A comprehensive search of the PubMed/MEDLINE, Web of Science, Scopus, Embase, and ProQuest (non-peer reviewed platform) was performed to answer the question \"Do DNA MMR system proteins exhibit expression in SGTs?\". The methodological quality of the selected studies was assessed using the JBI's Critical Appraisal Tool.Results: A total of 142 patients with benign SGTs and 84 with malignant SGTs were included in this review. The literature analysis showed a notable reduction in the expression of DNA MMR system proteins (hHMS2, hMLH1, hMSH3 and hMSH6) in the percentage of marked cells.Conclusions: The reduction in the expression of the DNA MMR system proteins suggests an interesting correlation with the development of malignant and benign SGTs. Nevertheless, further investigations are warranted to better clarify the precision of measuring biomarker protein expression.","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e655-e664"},"PeriodicalIF":1.8000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11365063/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicina Oral Patologia Oral Y Cirugia Bucal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4317/medoral.26647","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}

引用次数: 0

Abstract

Background: The DNA mismatch repair (MMR) system serves as a sophisticated guardian of the precise functioning of the human genome. Dysregulation within this system is linked to the oncogenesis process. Reduced expression of MMR system proteins identified in salivary gland tumors (SGTs) suggests an increased risk of tumoral occurrence. This study aims to analyze the expression of MMR proteins in SGTs and discuss the relevance of this association to the development of these neoplasms.

Material and methods: This review was conducted following the PRISMA guidelines and was registered in PROSPERO (CRD42023465590). A comprehensive search of the PubMed/MEDLINE, Web of Science, Scopus, Embase, and ProQuest (non-peer reviewed platform) was performed to answer the question "Do DNA MMR system proteins exhibit expression in SGTs?". The methodological quality of the selected studies was assessed using the JBI's Critical Appraisal Tool.

Results: A total of 142 patients with benign SGTs and 84 with malignant SGTs were included in this review. The literature analysis showed a notable reduction in the expression of DNA MMR system proteins (hHMS2, hMLH1, hMSH3 and hMSH6) in the percentage of marked cells.

Conclusions: The reduction in the expression of the DNA MMR system proteins suggests an interesting correlation with the development of malignant and benign SGTs. Nevertheless, further investigations are warranted to better clarify the precision of measuring biomarker protein expression.

查看原文本刊更多论文

唾液腺肿瘤中 DNA 错配修复系统的表达：系统综述。

背景：DNA 错配修复（MMR）系统是人类基因组精确运作的精密守护者。该系统的失调与肿瘤发生过程有关。在唾液腺肿瘤（SGTs）中发现的 MMR 系统蛋白表达减少表明肿瘤发生的风险增加。本研究旨在分析 MMR 蛋白在唾液腺肿瘤中的表达，并讨论这种关联与这些肿瘤发生的相关性：本综述按照 PRISMA 指南进行，并在 PROSPERO（CRD42023465590）上进行了注册。为了回答 "DNA MMR 系统蛋白在 SGTs 中是否有表达 "这一问题，对 PubMed/MEDLINE、Web of Science、Scopus、Embase 和 ProQuest（非同行评审平台）进行了全面检索。所选研究的方法学质量采用 JBI 的 "批判性评估工具 "进行评估：本综述共纳入了 142 例良性 SGT 患者和 84 例恶性 SGT 患者。文献分析显示，DNA MMR系统蛋白（hHMS2、hMLH1、hMSH3和hMSH6）的表达在标记细胞中的比例明显下降：结论：DNA MMR 系统蛋白表达的减少表明，恶性和良性 SGT 的发展之间存在着有趣的关联。尽管如此，仍需进一步研究，以更好地阐明生物标记蛋白表达测量的精确性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Medicina Oral Patologia Oral Y Cirugia Bucal DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

3-8 weeks

期刊介绍： 1. Oral Medicine and Pathology: Clinicopathological as well as medical or surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, as well as orofacial neurological disorders, and systemic conditions with an impact on the oral cavity. 2. Oral Surgery: Surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, teeth, implants, oral surgical procedures. Surgical management of diseases affecting head and neck areas. 3. Medically compromised patients in Dentistry: Articles discussing medical problems in Odontology will also be included, with a special focus on the clinico-odontological management of medically compromised patients, and considerations regarding high-risk or disabled patients. 4. Implantology 5. Periodontology