New objective simple evaluation methods of amyloid PET/CT using whole-brain histogram and Top20%-Map

IF 2.5 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Chio Okuyama, Tatsuya Higashi, Koichi Ishizu, Naoya Oishi, Kuninori Kusano, Miki Ito, Shinya Kagawa, Tomoko Okina, Norio Suzuki, Hiroshi Hasegawa, Yasuhiro Nagahama, Hiroyuki Watanabe, Masahiro Ono, Hiroshi Yamauchi
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Abstract

Objective

This study aims to assess the utility of newly developed objective methods for the evaluation of intracranial abnormal amyloid deposition using PET/CT histogram without use of cortical ROI analyses.

Methods

Twenty-five healthy volunteers (HV) and 38 patients with diagnosed or suspected dementia who had undergone 18F-FPYBF-2 PET/CT were retrospectively included in this study. Out of them, 11C-PiB PET/CT had been also performed in 13 subjects. In addition to the conventional methods, namely visual judgment and quantitative analyses using composed standardized uptake value ratio (comSUVR), the PET images were also evaluated by the following new parameters: the skewness and the mode-to-mean ratio (MMR) obtained from the histogram of the brain parenchyma; Top20%-map highlights the areas with high tracer accumulation occupying 20% volume of the total brain parenchymal on the individual’s CT images. We evaluated the utility of the new methods using histogram compared with the visual assessment and comSUVR. The results of these new methods between 18F-FPYBF-2 and 11C-PiB were also compared in 13 subjects.

Results

In visual analysis, 32, 9, and 22 subjects showed negative, border, and positive results, and composed SUVR in each group were 1.11 ± 0.06, 1.20 ± 0.13, and 1.48 ± 0.18 (p < 0.0001), respectively. Visually positive subjects showed significantly low skewness and high MMR (p < 0.0001), and the Top20%-Map showed the presence or absence of abnormal deposits clearly. In comparison between the two tracers, visual evaluation was all consistent, and the ComSUVR, the skewness, the MMR showed significant good correlation. The Top20%-Maps showed similar pattern.

Conclusions

Our new methods using the histogram of the brain parenchymal accumulation are simple and suitable for clinical practice of amyloid PET, and Top20%-Map on the individual’s brain CT can be of great help for the visual assessment.

Abstract Image

利用全脑直方图和 Top20% 地图对淀粉样蛋白 PET/CT 进行客观简单评估的新方法。
研究目的本研究旨在评估新开发的客观方法在不使用皮层 ROI 分析的情况下使用 PET/CT 直方图评估颅内异常淀粉样蛋白沉积的实用性:本研究回顾性地纳入了25名健康志愿者(HV)和38名接受过18F-FPYBF-2 PET/CT检查的确诊或疑似痴呆患者。其中,13 名受试者还接受了 11C-PiB PET/CT 检查。除了传统的方法,即肉眼判断和使用组成标准化摄取值比(comSUVR)进行定量分析外,PET 图像还通过以下新参数进行了评估:从脑实质直方图中获得的偏度和模均比(MMR);Top20%-map 可突出显示个人 CT 图像中占总脑实质体积 20% 的高示踪剂累积区域。与目测评估和 comSUVR 相比,我们评估了使用直方图的新方法的实用性。我们还在 13 名受试者中比较了 18F-FPYBF-2 和 11C-PiB 这两种新方法的结果:结果:在目测分析中,32、9 和 22 名受试者的结果分别为阴性、边界和阳性,每组的 SUVR 分别为 1.11 ± 0.06、1.20 ± 0.13 和 1.48 ± 0.18(p 结论:我们使用直方图和 comSUVR 的新方法对 18F-FPYBF-2 和 11C-PiB 的结果进行了比较:我们利用脑实质堆积直方图的新方法简单易行,适合淀粉样蛋白 PET 的临床实践,而个人脑 CT 上的 Top20%-Map 对直观评估有很大帮助。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annals of Nuclear Medicine
Annals of Nuclear Medicine 医学-核医学
CiteScore
4.90
自引率
7.70%
发文量
111
审稿时长
4-8 weeks
期刊介绍: Annals of Nuclear Medicine is an official journal of the Japanese Society of Nuclear Medicine. It develops the appropriate application of radioactive substances and stable nuclides in the field of medicine. The journal promotes the exchange of ideas and information and research in nuclear medicine and includes the medical application of radionuclides and related subjects. It presents original articles, short communications, reviews and letters to the editor.
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