Identifying risk factors for severe omicron infection in allogeneic hematopoietic stem cell transplant recipients with hematologic malignancies

IF 1.5 Q4 ONCOLOGY

Cancer reports Pub Date : 2024-06-21 DOI:10.1002/cnr2.2103

Zhihui Li, Lei Wang, Qinlong Zheng, Teng Xu, Keyan Yang, Xianxuan Wang, Xiaopei Wen, Caiyan Zhang, Jingjing Wang, Yanzhi Song, Yongqiang Zhao, Xiaoyu Zheng, Tong Wu

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引用次数: 0

Abstract

Background

In December 2022, a large-scale epidemic occurred in China due to Omicron variant of SARS-CoV-2. This study explored risk factors for Omicron infection in transplant recipients at our institution and investigated the factors influencing the severity of SARS-CoV-2 Omicron infection among recipients of allo-HSCT.

Methods

This single-center study investigated totally 63 allogeneic hematopoietic stem cell transplant patients infected with Omicron variant at the Beijing GoBroad Boren Hospital Transplant Center during December 2022 and analyzed their risk factors.

Results

The study included 63 allogeneic hematopoietic stem cell transplant patients who developed Omicron infection. There were 34 mild and 29 moderate to severe cases. Their median age was 22 years (range, 1–65 years), with the male-to-female ratio being 1:1.1. Acute myeloid leukemia (53.97%), acute lymphoblastic leukemia (42.86%), and non-Hodgkin lymphoma (3.17%) were underlying diseases. The median time between HCT and Omicron infection was 8.45 months. Significant predictive factors for moderate to severe Omicron infection included older age (p < .0001), cGVHD (p = .0195), concurrent bacterial infection (p < .0001), low absolute lymphocyte count (p = .026), low CD4/CD8 ratio (p = .0091), high CRP (p < .0001), high serum ferritin (p = .0023), high D-dimer (p < .0001), low CD4 absolute count (p = .0057), and low B-cell absolute count (p = .0154). A moderate to high HCT-CI score tended to be associated with moderate to severe infection (p = .0596).

Conclusion

This study indicates that risk factors for severe Omicron infection include certain clinical characteristics, such as age, cGVHD, and inflammatory response.

查看原文本刊更多论文

确定患有血液系统恶性肿瘤的异体造血干细胞移植受者发生严重奥米加环感染的风险因素

背景 2022年12月，SARS-CoV-2 Omicron变种在中国大规模流行。本研究探讨了本院移植受者感染 Omicron 的风险因素，并研究了影响异体造血干细胞移植受者感染 SARS-CoV-2 Omicron 严重程度的因素。方法本单中心研究调查了2022年12月北京果博东方博仁医院移植中心63例感染Omicron变异体的异基因造血干细胞移植患者，并分析了他们的风险因素。结果研究纳入了63例感染奥米克龙的异基因造血干细胞移植患者。其中轻度病例 34 例，中重度病例 29 例。他们的中位年龄为 22 岁（1-65 岁），男女比例为 1:1.1。急性髓性白血病（53.97%）、急性淋巴细胞白血病（42.86%）和非霍奇金淋巴瘤（3.17%）为基础疾病。从 HCT 到感染 Omicron 的中位时间为 8.45 个月。中度至重度奥米克龙感染的重要预测因素包括年龄偏大（p = .0001）、cGVHD（p = .0195）、并发细菌感染（p = .0001）、淋巴细胞绝对计数偏低（p = .026）、低 CD4/CD8 比率（p = .0091）、高 CRP（p <.0001）、高血清铁蛋白（p = .0023）、高 D-二聚体（p <.0001）、低 CD4 绝对计数（p = .0057）和低 B 细胞绝对计数（p = .0154）。中度至高度的 HCT-CI 评分往往与中度至重度感染相关（p = .0596）。结论本研究表明，重度奥美克龙感染的风险因素包括某些临床特征，如年龄、cGVHD 和炎症反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer reports Medicine-Oncology

CiteScore

2.70

自引率

5.90%

发文量

160

审稿时长

17 weeks