Serum leukemia inhibitory factor (LIF) levels in patients with Takayasu's and Giant cell arteritis: A cross-sectional study

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-06-01 DOI:10.1016/j.reuma.2024.02.005

Rahime Aksoy , Tahsin Murat Turgay , Recep Yilmaz , Serdar Sezer , Müçteba Enes Yayla , Emine Uslu Yurteri

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Abstract

Introduction and objectives

In this study, we aimed to evaluate LIF levels and its possible relationship with disease activity in patients with Takayasu's (TAK) and Giant cell arteritis (GCA) patients.

Materials and methods

23 Takayasu's arteritis, 9 Giant cell arteritis patients and 25 healthy volunteers were included in the study. Serum LIF levels were measured ELISA.

Results

The mean age of Giant cell arteritis patients was statistically significantly higher than the other groups (p < 0.001). The rate of women was found to be higher in Takayasu's arteritis (p = 0.021). When healthy control, patients with GCA and Takayasu arteritis were compared, there was a difference in LIF values (p = 0.018). In subgroup analyzes, LIF values were found to be higher in GCA patients compared to healthy controls (p < 0.05). There was no statistically significant correlation between LIF and CRP (Rho = −0.038, p = 0.778), ESR (Rho = 0.114, p = 0.399) and ITAS (Rho = −0.357, p = 0.094). While CRP was statistically significantly higher in patients with disease activity (p = 0.003), there was no statistically significant difference between patients in terms of ESR and LIF values. While there was a statistically significant relationship between CRP (OR = 1.19 [1.03–1.37], p = 0.018) and disease activity in univariate analyses, no statistically significant variable was found in multivariable analyses.

Conclusions

LIF values were significantly higher in patients with Giant cell arteritis compared to healthy controls.

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高安症和巨细胞动脉炎患者的血清白血病抑制因子 (LIF) 水平：横断面研究

导言和目的在这项研究中，我们旨在评估高安氏（TAK）和巨细胞动脉炎（GCA）患者的 LIF 水平及其与疾病活动的可能关系。结果巨细胞动脉炎患者的平均年龄在统计学上明显高于其他组别（p <0.001）。高安氏动脉炎患者中女性比例更高（p = 0.021）。健康对照组、GCA 患者和高安动脉炎患者的 LIF 值存在差异（p = 0.018）。在亚组分析中发现，与健康对照组相比，GCA 患者的 LIF 值更高（p <0.05）。LIF 与 CRP（Rho = -0.038，p = 0.778）、ESR（Rho = 0.114，p = 0.399）和 ITAS（Rho = -0.357，p = 0.094）之间没有统计学意义上的相关性。在统计学上，疾病活动期患者的 CRP 明显更高（p = 0.003），但在统计学上，不同患者的 ESR 和 LIF 值没有明显差异。在单变量分析中，CRP（OR = 1.19 [1.03-1.37]，p = 0.018）与疾病活动性之间存在统计学意义上的显著关系，但在多变量分析中未发现统计学意义上的显著变量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.