Cordyceps militaris: A novel mushroom platform for metabolic engineering

IF 12.1 1区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biotechnology advances Pub Date : 2024-06-19 DOI:10.1016/j.biotechadv.2024.108396

Jiapeng Zeng , Yue Zhou , Mengdi Lyu , Xinchang Huang , Muyun Xie , Mingtao Huang , Bai-Xiong Chen , Tao Wei

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Abstract

Cordyceps militaris, widely recognized as a medicinal and edible mushroom in East Asia, contains a variety of bioactive compounds, including cordycepin (COR), pentostatin (PTN) and other high-value compounds. This review explores the potential of developing C. militaris as a cell factory for the production of high-value chemicals and nutrients. This review comprehensively summarizes the fermentation advantages, metabolic networks, expression elements, and genome editing tools specific to C. militaris and discusses the challenges and barriers to further research on C. militaris across various fields, including computational biology, existing DNA elements, and genome editing approaches. This review aims to describe specific and promising opportunities for the in-depth study and development of C. militaris as a new chassis cell. Additionally, to increase the practicability of this review, examples of the construction of cell factories are provided, and promising strategies for synthetic biology development are illustrated.

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冬虫夏草：用于代谢工程的新型蘑菇平台

冬虫夏草是东亚地区公认的药用和食用菌，含有多种生物活性化合物，包括虫草素（COR）、喷司他丁（PTN）和其他高价值化合物。这篇综述探讨了开发冬菇作为生产高价值化学品和营养品的细胞工厂的潜力。本综述全面总结了 C. militaris 特有的发酵优势、代谢网络、表达元件和基因组编辑工具，并讨论了在各个领域进一步研究 C. militaris 所面临的挑战和障碍，包括计算生物学、现有 DNA 元件和基因组编辑方法。本综述旨在描述将 C. militaris 作为新底盘细胞进行深入研究和开发的具体而有前景的机会。此外，为了提高本综述的实用性，还提供了构建细胞工厂的实例，并说明了合成生物学发展的可行策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biotechnology advances 工程技术-生物工程与应用微生物

CiteScore

25.50

自引率

2.50%

发文量

167

审稿时长

37 days

期刊介绍： Biotechnology Advances is a comprehensive review journal that covers all aspects of the multidisciplinary field of biotechnology. The journal focuses on biotechnology principles and their applications in various industries, agriculture, medicine, environmental concerns, and regulatory issues. It publishes authoritative articles that highlight current developments and future trends in the field of biotechnology. The journal invites submissions of manuscripts that are relevant and appropriate. It targets a wide audience, including scientists, engineers, students, instructors, researchers, practitioners, managers, governments, and other stakeholders in the field. Additionally, special issues are published based on selected presentations from recent relevant conferences in collaboration with the organizations hosting those conferences.