Leptomeningeal metastases from solid tumors: A Society for Neuro-Oncology and American Society of Clinical Oncology consensus review on clinical management and future directions.

IF 16.4 1区 医学 Q1 CLINICAL NEUROLOGY
Jessica A Wilcox, Ugonma N Chukwueke, Myung-Ju Ahn, Ayal A Aizer, Tejus A Bale, Dieta Brandsma, Priscilla K Brastianos, Susan Chang, Mariza Daras, Peter Forsyth, Livia Garzia, Michael Glantz, Isabella C Glitza Oliva, Priya Kumthekar, Emilie Le Rhun, Seema Nagpal, Barbara O'Brien, Elena Pentsova, Eudocia Quant Lee, Jan Remsik, Roberta Rudà, Inna Smalley, Michael D Taylor, Michael Weller, Jeffrey Wefel, Jonathan T Yang, Robert J Young, Patrick Y Wen, Adrienne A Boire
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引用次数: 0

Abstract

Leptomeningeal metastases (LM) are increasingly becoming recognized as a treatable, yet generally incurable, complication of advanced cancer. As modern cancer therapeutics have prolonged the lives of patients with metastatic cancer, specifically in patients with parenchymal brain metastases, treatment options, and clinical research protocols for patients with LM from solid tumors have similarly evolved to improve survival within specific populations. Recent expansions in clinical investigation, early diagnosis, and drug development have given rise to new unanswered questions. These include leptomeningeal metastasis biology and preferred animal modeling, epidemiology in the modern cancer population, ensuring validation and accessibility of newer leptomeningeal metastasis diagnostics, best clinical practices with multimodality treatment options, clinical trial design and standardization of response assessments, and avenues worthy of further research. An international group of multi-disciplinary experts in the research and management of LM, supported by the Society for Neuro-Oncology and American Society of Clinical Oncology, were assembled to reach a consensus opinion on these pressing topics and provide a roadmap for future directions. Our hope is that these recommendations will accelerate collaboration and progress in the field of LM and serve as a platform for further discussion and patient advocacy.

实体瘤的脑膜转移:关于临床管理和未来方向的 SNO 和 ASCO 共识综述。
人们日益认识到,脑膜转移是晚期癌症的一种可治疗但通常无法治愈的并发症。随着现代癌症疗法延长了转移性癌症患者的生命,特别是脑实质转移患者的生命,针对实体瘤脑膜转移患者的治疗方案和临床研究方案也同样得到了发展,以提高特定人群的生存率。近来,临床研究、早期诊断和药物开发领域的扩展引发了新的未解之谜。这些问题包括脑膜转移生物学和首选动物模型、现代癌症人群的流行病学、确保更新的脑膜转移诊断方法的有效性和可及性、多模式治疗方案的最佳临床实践、临床试验设计和反应评估的标准化,以及值得进一步研究的途径。在神经肿瘤学会(Society for Neuro-Oncology)和美国临床肿瘤学会(American Society of Clinical Oncology)的支持下,研究和治疗脑转移瘤的多学科专家组成了一个国际小组,就这些紧迫的课题达成了共识,并为未来的发展方向提供了路线图。我们希望这些建议能加快脑膜外转移领域的合作与进步,并为进一步的讨论和患者权益维护提供一个平台。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Neuro-oncology
Neuro-oncology 医学-临床神经学
CiteScore
27.20
自引率
6.30%
发文量
1434
审稿时长
3-8 weeks
期刊介绍: Neuro-Oncology, the official journal of the Society for Neuro-Oncology, has been published monthly since January 2010. Affiliated with the Japan Society for Neuro-Oncology and the European Association of Neuro-Oncology, it is a global leader in the field. The journal is committed to swiftly disseminating high-quality information across all areas of neuro-oncology. It features peer-reviewed articles, reviews, symposia on various topics, abstracts from annual meetings, and updates from neuro-oncology societies worldwide.
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