Enhancement of chemotherapy effects by non-lethal magneto-mechanical actuation of gold-coated magnetic nanoparticles

IF 4.2 2区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2024-06-18 DOI:10.1016/j.nano.2024.102766

Cristina Stavilă PhD student , Dumitru Daniel Herea PhD , Mihaela Camelia Zară PhD , George Stoian PhD , Anca Emanuela Minuti PhD , Luminița Labușcă PhD - MD , Marian Grigoraș PhD , Horia Chiriac PhD , Nicoleta Lupu PhD , Adriana Petrovici PhD student , Adriana Aniță PhD - MD , Dragos Aniță PhD - MD

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Abstract

Remote magneto-mechanical actuation (MMA) of magnetic nanoparticles (MNP) is emerging as a promising therapy method in oncology. However, translation to the clinic faces the challenge of whole-body action and the reluctance about indiscriminate mechanical action of the nanoparticles on tumor and healthy cells. Here, we show how the MMA method based on magnetically-rotated gold-coated MNP boosts only the activity of an unbound antitumor drug, without physical damage of cells via MNP. Therefore, in clinical practice, the effect of antitumor drug can be safely increased systemically while maintaining drug concentrations at current doses.

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通过金涂层磁性纳米粒子的非致命磁机械致动增强化疗效果。

磁性纳米粒子（MNP）的远程磁机械致动（MMA）正在成为肿瘤学中一种前景广阔的治疗方法。然而，将这种方法应用于临床面临着全身作用的挑战，以及人们对纳米粒子对肿瘤和健康细胞无差别机械作用的不情愿。在这里，我们展示了基于磁旋转金涂层 MNP 的 MMA 方法如何仅提高未结合抗肿瘤药物的活性，而不会通过 MNP 对细胞造成物理损伤。因此，在临床实践中，可以安全地提高全身抗肿瘤药物的效果，同时将药物浓度保持在现有剂量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nanomedicine : nanotechnology, biology, and medicine 工程技术-纳米科技

CiteScore

11.10

自引率

0.00%

发文量

133

审稿时长

42 days

期刊介绍： The mission of Nanomedicine: Nanotechnology, Biology, and Medicine (Nanomedicine: NBM) is to promote the emerging interdisciplinary field of nanomedicine. Nanomedicine: NBM is an international, peer-reviewed journal presenting novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in the life and health sciences. Content includes basic, translational, and clinical research addressing diagnosis, treatment, monitoring, prediction, and prevention of diseases.