Impact of inflammasomes on the ocular surface.

IF 3 4区医学 Q2 ALLERGY

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-10-01 Epub Date: 2024-06-20 DOI:10.1097/ACI.0000000000001004

Gwen S Stinnett, Chuan-Hui Kuo, Santa J Ono

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引用次数: 0

Abstract

Purpose of review: The ocular surface is prone to inflammation due to exposure to environmental irritants and pathogens. Inflammasomes are intracellular, multiprotein complexes that communicate potentially dangerous signals to the immune system. The identification of inflammasomes in various inflammatory ocular surface conditions can aid in the development of therapeutics to treat these chronic inflammatory conditions.

Recent findings: Several inflammasomes have been associated with ocular surface disorders including dry eye disease, keratitis, and allergies. Mechanisms for activation of these inflammasomes with regards to specific disorders have been explored in models to aid in the development of targeted treatments.

Summary: Research efforts continue to characterize the types of inflammasomes and activators of these in inflammatory ocular surface conditions. Various therapies targeting specific inflammasome types or pyroptosis are being tested preclinically to assess effects on decreasing the associated chronic inflammation.

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炎性体对眼表的影响。

审查目的：由于暴露于环境刺激物和病原体，眼表很容易发生炎症。炎症体是一种细胞内多蛋白复合物，可向免疫系统传递潜在的危险信号。在各种炎症性眼表疾病中识别炎症体有助于开发治疗这些慢性炎症的疗法：一些炎症体与干眼症、角膜炎和过敏症等眼表疾病有关。我们在模型中探索了这些炎性体激活特定疾病的机制，以帮助开发有针对性的治疗方法：研究工作仍在继续，以确定炎症性眼表疾病中的炎性体类型及其激活剂的特征。目前正在对针对特定炎性体类型或炎症蛋白酶活性的各种疗法进行临床前测试，以评估其对减轻相关慢性炎症的效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Allergy and Clinical Immunology 医学-过敏

CiteScore

5.90

自引率

3.60%

发文量

109

审稿时长

6-12 weeks

期刊介绍： This reader-friendly, bimonthly resource provides a powerful, broad-based perspective on the most important advances from throughout the world literature. Featuring renowned guest editors and focusing exclusively on one to three topics, every issue of Current Opinion in Allergy and Clinical Immunology delivers unvarnished, expert assessments of developments from the previous year. Insightful editorials and on-the-mark invited reviews cover key subjects such as upper airway disease; mechanisms of allergy and adult asthma; paediatric asthma and development of atopy; food and drug allergies; and immunotherapy.