Diagnostic performance of quantitative ultrasonography for hepatic steatosis in a health screening program: a prospective single-center study.

IF 2.4 3区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Ultrasonography Pub Date : 2024-07-01 Epub Date: 2024-05-29 DOI:10.14366/usg.24040

Jeung Hui Pyo, Soo Jin Cho, Sung Chul Choi, Jae Hwan Jee, Jeeyeong Yun, Jeong Ah Hwang, Goeun Park, Kyunga Kim, Wonseok Kang, Mira Kang, Young Hye Byun

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Abstract

Purpose: This study compared the diagnostic performance of quantitative ultrasonography (QUS) with that of conventional ultrasonography (US) in assessing hepatic steatosis among individuals undergoing health screening using magnetic resonance imaging-derived proton density fat fraction (MRI-PDFF) as the reference standard.

Methods: This single-center prospective study enrolled 427 participants who underwent abdominal MRI and US. Measurements included the attenuation coefficient in tissue attenuation imaging (TAI) and the scatter-distribution coefficient in tissue scatter-distribution imaging (TSI). The correlation between QUS and MRI-PDFF was evaluated. The diagnostic capabilities of QUS, conventional B-mode US, and their combined models for detecting hepatic fat content of ≥5% (MRI-PDFF ≥5%) and ≥10% (MRI-PDFF ≥10%) were compared by analyzing the areas under the receiver operating characteristic curves. Additionally, clinical risk factors influencing the diagnostic performance of QUS were identified using multivariate linear regression analyses.

Results: TAI and TSI were strongly correlated with MRI-PDFF (r=0.759 and r=0.802, respectively; both P<0.001) and demonstrated good diagnostic performance in detecting and grading hepatic steatosis. The combination of QUS and B-mode US resulted in the highest areas under the ROC curve (AUCs) (0.947 and 0.975 for detecting hepatic fat content of ≥5% and ≥10%, respectively; both P<0.05), compared to TAI, TSI, or B-mode US alone (AUCs: 0.887, 0.910, 0.878 for ≥5% and 0.951, 0.922, 0.875 for ≥10%, respectively). The independent determinants of QUS included skinliver capsule distance (β=7.134), hepatic fibrosis (β=4.808), alanine aminotransferase (β=0.202), triglyceride levels (β=0.027), and diabetes mellitus (β=3.710).

Conclusion: QUS is a useful and effective screening tool for detecting and grading hepatic steatosis during health checkups.

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健康筛查项目中定量超声波肝脂肪变性的诊断性能：一项前瞻性单中心研究。

目的：本研究以磁共振成像衍生质子密度脂肪分数（MRI-PDFF）为参考标准，比较了定量超声波成像（QUS）与传统超声波成像（US）在评估健康检查人群肝脂肪变性方面的诊断性能：这项单中心前瞻性研究共纳入 427 名接受腹部磁共振成像和超声波检查的人员。测量包括组织衰减成像（TAI）中的衰减系数和组织散射分布成像（TSI）中的散射分布系数。对 QUS 和 MRI-PDFF 之间的相关性进行了评估。通过分析接收者操作特征曲线下的面积，比较了 QUS、传统 B 型 US 及其组合模型检测肝脏脂肪含量≥5%（MRI-PDFF ≥5%）和≥10%（MRI-PDFF ≥10%）的诊断能力。此外，还利用多变量线性回归分析确定了影响 QUS 诊断性能的临床风险因素：结果：TAI和TSI与MRI-PDFF密切相关（分别为r=0.759和r=0.802；均为P<0.001），在肝脏脂肪变性的检测和分级方面表现出良好的诊断性能。与单独使用 TAI、TSI 或 B 型 US 相比，联合使用 QUS 和 B 型 US 可获得最高的 ROC 曲线下面积（AUCs）（检测肝脏脂肪含量≥5% 和≥10% 分别为 0.947 和 0.975；均为 P<0.05）（AUCs：检测肝脏脂肪含量≥5% 分别为 0.887、0.910、0.878，检测肝脏脂肪含量≥10% 分别为 0.951、0.922、0.875）。QUS的独立决定因素包括皮肝囊距离（β=7.134）、肝纤维化（β=4.808）、丙氨酸氨基转移酶（β=0.202）、甘油三酯水平（β=0.027）和糖尿病（β=3.710）：结论：QUS 是健康体检中检测和分级肝脂肪变性的有效筛查工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ultrasonography Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

5.10

自引率

6.50%

发文量

审稿时长

15 weeks

期刊介绍： Ultrasonography, the official English-language journal of the Korean Society of Ultrasound in Medicine (KSUM), is an international peer-reviewed academic journal dedicated to practice, research, technology, and education dealing with medical ultrasound. It is renamed from the Journal of Korean Society of Ultrasound in Medicine in January 2014, and published four times per year: January 1, April 1, July 1, and October 1. Original articles, technical notes, topical reviews, perspectives, pictorial essays, and timely editorial materials are published in Ultrasonography covering state-of-the-art content. Ultrasonography aims to provide updated information on new diagnostic concepts and technical developments, including experimental animal studies using new equipment in addition to well-designed reviews of contemporary issues in patient care. Along with running KSUM Open, the annual international congress of KSUM, Ultrasonography also serves as a medium for cooperation among physicians and specialists from around the world who are focusing on various ultrasound technology and disease problems and relevant basic science.