Effect of Yoga-Based Cardiac Rehabilitation Program on Endothelial Function, Oxidative Stress, and Inflammatory Markers in Acute Myocardial Infarction: A Randomized Controlled Trial.

IF 1.1 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE
International Journal of Yoga Pub Date : 2024-01-01 Epub Date: 2024-05-13 DOI:10.4103/ijoy.ijoy_40_24
Satish Gurunathrao Patil, Edmin Christa Sobitharaj, Ambalam Mahendrakumar Chandrasekaran, Shankar S Patil, Kalpana Singh, Ruby Gupta, Kishore Kumar Deepak, Ashok Kumar Jaryal, Dinu Santha Chandran, Sanjay Kinra, Ambuj Roy, Dorairaj Prabhakaran
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引用次数: 0

Abstract

Aims: The aim of this study was to evaluate the effects of yoga-based cardiac rehabilitation (Yoga-CaRe) on the endothelial system, oxidative stress, and inflammatory markers in patients with acute myocardial infarction (MI).

Methods: A sub-study was conducted in two clinical sites of the Yoga-CaRe trial (a multicenter randomized controlled trial). Participants with acute MI were randomized and allocated to either the Yoga-CaRe program (13 sessions with encouragement to home practice) or enhanced standard care (three educational sessions). Endothelial function, oxidative stress, and inflammatory biomarkers were assessed using biomarkers such as asymmetric dimethylarginine (ADMA), endothelial nitric oxide synthase (eNOS), endothelin-1 (ET-1), E-selectin, P-selectin, vascular cell adhesion molecule (VCAM), intercellular cell-adhesion molecule-1, total nitric oxide concentration (NOx), oxidized low-density lipoprotein (Oxd-LDL), superoxide dismutase, total antioxidant capacity (TAOC), tumor necrosis factor-alpha (TNFα), and C-reactive protein (CRP) at baseline and 12 weeks. Laboratory and statistical analysis were done by staff blinded to group allocation.

Results: Eighty-two patients (of the 110 patients recruited) completed the study. The mean age was 53.1 ± 10.6 and 51.9 ± 10.7 years in enhanced standard care and Yoga-CaRe group, respectively. At 12 weeks, Yoga-CaRe significantly reduced ADMA, ET-1, and ICMA-1 than the enhanced standard care group. Although E-selectin and VCAM at 12 weeks were reduced in both groups, enhanced standard care had a significantly higher reduction than the Yoga-CaRe group. Among markers of oxidative stress, TAOC increased in the Yoga-CaRe group. We found no difference in eNOS, NOx, P-selectin, TNFα, CRP, and Oxd-LDL between the two groups.

Conclusion: Yoga-CaRe improved the endothelial function (through a reduction in ET-1 and modulating adhesion molecules) and enhanced antioxidant capacity.

基于瑜伽的心脏康复计划对急性心肌梗死患者内皮功能、氧化应激和炎症标志物的影响:随机对照试验
目的:本研究旨在评估基于瑜伽的心脏康复(Yoga-CaRe)对急性心肌梗死(MI)患者的内皮系统、氧化应激和炎症指标的影响:在瑜伽-CaRe 试验(多中心随机对照试验)的两个临床基地开展了一项子研究。急性心肌梗死患者被随机分配到瑜伽-CaRe项目(13次课程,并鼓励其在家练习)或强化标准护理(3次教育课程)中。使用不对称二甲基精氨酸(ADMA)、内皮一氧化氮合酶(eNOS)、内皮素-1(ET-1)、E-选择素、P-选择素、血管细胞粘附分子(VCAM)等生物标志物评估内皮功能、氧化应激和炎症生物标志物、在基线和 12 周时,研究人员会检测一氧化氮总浓度 (NOx)、氧化低密度脂蛋白 (Oxd-LDL)、超氧化物歧化酶、总抗氧化能力 (TAOC)、肿瘤坏死因子-α (TNFα) 和 C 反应蛋白 (CRP)。实验室和统计分析由对组别分配保密的工作人员进行:在招募的 110 名患者中,有 82 名患者完成了研究。加强标准护理组和瑜伽-CaRe 组的平均年龄分别为(53.1 ± 10.6)岁和(51.9 ± 10.7)岁。12 周时,Yoga-CaRe 比增强型标准护理组明显降低了 ADMA、ET-1 和 ICMA-1。虽然在 12 周时,两组的 E-选择素和 VCAM 都有所减少,但强化标准护理组的减少幅度明显高于瑜伽-CaRe 组。在氧化应激指标中,TAOC 在瑜伽-CaRe 组中有所增加。我们发现两组之间的 eNOS、NOx、P-选择素、TNFα、CRP 和 Oxd-LDL 均无差异:结论:瑜伽-CaRe 可改善内皮功能(通过减少 ET-1 和调节粘附分子)并增强抗氧化能力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
International Journal of Yoga
International Journal of Yoga INTEGRATIVE & COMPLEMENTARY MEDICINE-
自引率
12.50%
发文量
37
审稿时长
24 weeks
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