Male Fertility in Spondyloarthritis: from Clinical Issues to Cytokines Milieu. A Narrative Review.

IF 5.7 2区 医学 Q1 RHEUMATOLOGY
Current Rheumatology Reports Pub Date : 2024-09-01 Epub Date: 2024-06-20 DOI:10.1007/s11926-024-01153-w
Silvia Scriffignano, Fabio Massimo Perrotta, Ennio Lubrano
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Abstract

Purposeof review: Male fertility is an emergent issue that should be considered in clinical practice, when dealing with chronic inflammatory diseases in young men. As it is known, the chronic inflammation is the main pathophysiologic mechanism in some rheumatological conditions such as spondyloarthritis (SpA), Ankylosing Spondylitis (AS) and Psoriatic Arthritis (PsA). Therefore, it is paramount to be aware if these diseases could impair male fertility, both due to the inflammation or to the treatments needed: we reviewed the literature on the most relevant and recent evidence on male fertility in patients affected by SpA, AS and PsA.

Recent findings: Rheumatological inflammatory diseases (included SpA, AS and PsA) could impair the family planning in man life, especially when diagnosed at young age. Moreover, focusing on sperm quality, it seems that a link between sperm quality impairment and a higher disease activity exist. Focusing on therapies, Tumor Necrosis Factor inhibitors showed a safety profile on human male fertility in clinical studies. Recently, a prospective study and two double-blind placebo-controlled trials assessed the impact of methotrexate and Filgotinib on semen parameters, respectively, showing a safety profile of these drugs on human semen quality. However, there are no clinical data on the impact of Interleukin (IL)17 inhibitors(i), IL12-23i and IL23i. Concerning male fertility in SpA, AS and PsA, an unmet clinical need is still present and new studies are needed to understand the association between these diseases and male fertility, and the implication of the therapies used for these diseases. This narrative review provides an overview of the available data on male fertility in patients affected by SpA, AS and PsA.

Abstract Image

脊柱关节炎的男性生育能力:从临床问题到细胞因子环境。叙述性综述。
综述目的:在临床实践中,当处理年轻男性的慢性炎症性疾病时,男性生育力是一个需要考虑的新问题。众所周知,慢性炎症是脊柱关节炎(SpA)、强直性脊柱炎(AS)和银屑病关节炎(PsA)等风湿病的主要病理生理机制。因此,最重要的是要了解这些疾病是否会因炎症或所需治疗而损害男性生育能力:我们回顾了与 SpA、AS 和 PsA 患者的男性生育能力最相关的最新证据文献:风湿性炎症疾病(包括SpA、AS和PsA)会影响男性的计划生育,尤其是在年轻时确诊的患者。此外,就精子质量而言,精子质量受损与疾病活动性增高之间似乎存在联系。在治疗方面,肿瘤坏死因子抑制剂在临床研究中显示出对男性生育能力的安全性。最近,一项前瞻性研究和两项双盲安慰剂对照试验分别评估了甲氨蝶呤和菲戈替尼对精液参数的影响,结果显示这些药物对人类精液质量具有安全性。然而,目前还没有关于白细胞介素(IL)17抑制剂(i)、IL12-23i和IL23i影响的临床数据。关于SpA、AS和PsA患者的男性生育力,目前仍有临床需求未得到满足,需要进行新的研究以了解这些疾病与男性生育力之间的关联,以及用于这些疾病的疗法的影响。本综述概述了有关SpA、AS和PsA患者男性生育力的现有数据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
11.20
自引率
0.00%
发文量
41
期刊介绍: This journal aims to review the most important, recently published research in the field of rheumatology. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care and prevention of rheumatologic conditions. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas such as the many forms of arthritis, osteoporosis and metabolic bone disease, and systemic lupus erythematosus. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also occasionally provided.
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