Determination of phytochemical contents by LC/QTOF/MS and evaluation of in-vitro biological activities of 2 Peltigera lichens from Bursa.

IF 1.1 4区综合性期刊 Q3 MULTIDISCIPLINARY SCIENCES

Anais da Academia Brasileira de Ciencias Pub Date : 2024-06-14 eCollection Date: 2024-01-01 DOI:10.1590/0001-3765202420230657

Burcu S Tüzün, Başak T Karadağ, Seyhan Oran, Şule Öztürk, Fethiye F Yilmaz, Tuğçe Fafal, Bijen Kivçak

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Abstract

Lichens are symbiotic associations of algae and fungi. They are edible as food and have been used in traditional medicine for years. It is aimed to screen Peltigera praetextata (Flörke ex Sommerf.) Zopfand and Peltigera elisabethae Gyeln. phytochemically by LC/QTOF/MS and according to the constituents to evaluate the antioxidant, tyrosinase inhibitory, and antibacterial activities. In total 54 of metabolites detected by LC/QTOF/MS were common in both species. According to LC/QTOF/MS scanning results, alkaloids, iridoid glycosides, phenolics, cyanogenetic glycosides, and terpenic structures were detected. DPPH, ABTS, superoxide radical scavenging activities, and metal chelating capacity IC50 values were 84.55, 9.349; 51.27, 9.127; 95.01, 58.65 and 20.57, 70.08 µg/mL., respectively. The CUPRAC reducing power was determined as 4.69 and 9.57 TEACCUPRAC, respectively. Tyrosinase inhibitor activity were found to be 86.95 and 196.7 µg/mL. Both lichens did not show antimicrobial effects. As a result of the antioxidant and tyrosinase inhibitor activities it was seen that their activities were significant and further in vivo studies could be carried out on this lichens.

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用 LC/QTOF/MS 测定布尔萨 2 种 Peltigera 地衣的植物化学成分含量并评估其体外生物活性。

地衣是藻类和真菌的共生体。地衣可作为食物食用，多年来一直被用于传统医药。本研究旨在通过 LC/QTOF/MS 对 Peltigera praetextata (Flörke ex Sommerf.) Zopfand 和 Peltigera elisabethae Gyeln 进行植物化学筛选，并根据其成分评估其抗氧化、抑制酪氨酸酶和抗菌活性。通过 LC/QTOF/MS 检测到的代谢物中共有 54 种在两种植物中都存在。根据 LC/QTOF/MS 扫描结果，检测到生物碱、鸢尾苷、酚类、氰基苷和萜类结构。DPPH、ABTS、超氧自由基清除活性和金属螯合能力 IC50 值分别为 84.55、9.349；51.27、9.127；95.01、58.65 和 20.57、70.08 µg/mL。测定的 CUPRAC 还原能力分别为 4.69 和 9.57 TEACCUPRAC。酪氨酸酶抑制活性分别为 86.95 和 196.7 µg/mL。两种地衣都没有显示出抗菌作用。从抗氧化剂和酪氨酸酶抑制剂活性的结果来看，它们的活性是显著的，可以对这种地衣进行进一步的体内研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anais da Academia Brasileira de Ciencias 综合性期刊-综合性期刊

CiteScore

2.20

自引率

0.00%

发文量

347

审稿时长

1 months

期刊介绍： The Brazilian Academy of Sciences (BAS) publishes its journal, Annals of the Brazilian Academy of Sciences (AABC, in its Brazilianportuguese acronym ), every 3 months, being the oldest journal in Brazil with conkinuous distribukion, daking back to 1929. This scienkihic journal aims to publish the advances in scienkihic research from both Brazilian and foreigner scienkists, who work in the main research centers in the whole world, always looking for excellence. Essenkially a mulkidisciplinary journal, the AABC cover, with both reviews and original researches, the diverse areas represented in the Academy, such as Biology, Physics, Biomedical Sciences, Chemistry, Agrarian Sciences, Engineering, Mathemakics, Social, Health and Earth Sciences.

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