The prevalence and genotype distribution of high-risk human papillomaviruses among women in Xianning, China.

IF 4 3区医学 Q2 VIROLOGY

Virology Journal Pub Date : 2024-06-18 DOI:10.1186/s12985-024-02413-y

Bin Qiu, Na Jiang, Jinpeng Jiang, Xuebao Mao, Xiuhong Wang

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引用次数: 0

Abstract

Background: The persistent infection of high-risk Human papillomavirus(HPV) is considered the main cause of cervical intraepithelial neoplasia and cervical cancer. But various cervical lesions caused by HPV infection can be properly prevented by timely vaccination. However, the distribution of HPV genotypes varies geographically.

Methods: Retrospective analysis of high-risk HPV prevalence of 16,150 women from 2020 to 2022 in xianning of China. HPV genotyping was performed using a PCR-RDB Kit that can detect 18 high-risk HPV genotypes recommended by China's National Medical Products Administration. The prevalence of 18 high-risk HPV genotypes and their relationship with cervical lesions as well as vaccine efficacy were analyzed.

Results: A total of 2431 women were confirmed to have different types of high-risk HPV infections. The overall positive rate reached 15.05%(2431/16,150). The most prevalent high-risk HPV genotypes were HPV52, 16, 58, 53, and 51. The prevalence of high-risk HPV reached peak at age ≤ 20(20.95%) and age ≥ 61(20.56%). The most prevalent high-risk HPV genotypes were HPV16, 58, 18, 33 and 52 in cervical cancer cases, HPV16, 52, 58, 33 and 18 in CIN2/3 cases, and HPV52, 58, 16, 53 and 18 in CIN1 cases, respectively.

Conclusion: HPV16, 58 and 18 are the most dangerous and carcinogenic genotypes in xianning, China. Conducting epidemiological investigations on high-risk HPV has significant clinical value in guiding HPV vaccination work.

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中国咸宁妇女中高危人乳头瘤病毒的流行率和基因型分布。

背景：高危人乳头瘤病毒（HPV）的持续感染被认为是宫颈上皮内瘤变和宫颈癌的主要病因。但通过及时接种疫苗，可以很好地预防由 HPV 感染引起的各种宫颈病变。然而，HPV 基因型的分布因地域而异：方法：回顾性分析 2020 年至 2022 年中国咸宁 16150 名妇女的高危 HPV 感染情况。HPV基因分型采用PCR-RDB试剂盒进行，该试剂盒可检测中国国家医药产品管理局推荐的18种高危HPV基因型。分析了18种高危HPV基因型的流行情况及其与宫颈病变和疫苗疗效的关系：结果：共有 2431 名妇女被确诊感染了不同类型的高危型 HPV。总体阳性率达到 15.05%（2431/16,150）。最常见的高危型 HPV 基因型为 HPV52、16、58、53 和 51。高危型 HPV 的感染率在年龄≤20 岁（20.95%）和年龄≥61 岁（20.56%）时达到高峰。宫颈癌病例中最常见的高危 HPV 基因型分别是 HPV16、58、18、33 和 52，CIN2/3 病例中最常见的高危 HPV 基因型分别是 HPV16、52、58、33 和 18，CIN1 病例中最常见的高危 HPV 基因型分别是 HPV52、58、16、53 和 18：HPV16、58和18是中国咸宁地区最危险的致癌基因型。结论：HPV16、58和18是中国咸宁地区最危险的致癌基因型，开展高危HPV流行病学调查对指导HPV疫苗接种工作具有重要的临床价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Virology Journal 医学-病毒学

CiteScore

7.40

自引率

2.10%

发文量

186

审稿时长

1 months

期刊介绍： Virology Journal is an open access, peer reviewed journal that considers articles on all aspects of virology, including research on the viruses of animals, plants and microbes. The journal welcomes basic research as well as pre-clinical and clinical studies of novel diagnostic tools, vaccines and anti-viral therapies. The Editorial policy of Virology Journal is to publish all research which is assessed by peer reviewers to be a coherent and sound addition to the scientific literature, and puts less emphasis on interest levels or perceived impact.