Digest: Resource limitation as a mechanism for constraining the evolution of virulence in malaria parasites.

IF 3.1 2区 环境科学与生态学 Q2 ECOLOGY
Evolution Pub Date : 2024-07-29 DOI:10.1093/evolut/qpae094
Sophie Lockwood
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引用次数: 0

Abstract

The virulence of parasites is expected to reflect an evolutionary tradeoff between increasing proliferation rates that enhance transmission and host mortality which curtails transmission. However, host resource availability may also limit parasites' proliferation rate. To understand the role of resource limitation as a driver of virulence evolution, Pak et al. (2024) use a within-host model of red blood cell (RBC) invasion by Plasmodium chabaudi. They find that within-host resource consumption limits the evolution of the parasite's proliferation rate, as the depletion of RBCs during infection results in intermediate optimal virulence. These results suggest that resource limitation, rather than host mortality, may drive the evolution of virulence.

摘要:资源限制是制约疟疾寄生虫毒力进化的机制。
寄生虫的致病力预计反映了提高增殖率以加强传播与降低宿主死亡率以遏制传播之间的进化权衡。然而,宿主资源的可用性也可能限制寄生虫的增殖率。为了了解资源限制作为毒力进化驱动力的作用,Pak 等人(2024 年)使用了一个由恰鲍迪疟原虫入侵红血细胞(RBC)的宿主内模型。他们发现,宿主内资源消耗限制了寄生虫增殖率的进化,因为感染期间红细胞的耗竭会导致中间最佳毒力。这些结果表明,资源限制而非宿主死亡可能是毒力进化的驱动力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Evolution
Evolution 环境科学-进化生物学
CiteScore
5.00
自引率
9.10%
发文量
0
审稿时长
3-6 weeks
期刊介绍: Evolution, published for the Society for the Study of Evolution, is the premier publication devoted to the study of organic evolution and the integration of the various fields of science concerned with evolution. The journal presents significant and original results that extend our understanding of evolutionary phenomena and processes.
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