Mass Spectrometry Imaging Techniques: Non-Ambient and Ambient Ionization Approaches.

IF 4.2 2区 化学 Q1 CHEMISTRY, ANALYTICAL
Shundi Hu, Ahsan Habib, Wei Xiong, La Chen, Lei Bi, Luhong Wen
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引用次数: 0

Abstract

Molecular information can be acquired from sample surfaces in real time using a revolutionary molecular imaging technique called mass spectrometry imaging (MSI). The technique can concurrently provide high spatial resolution information on the spatial distribution and relative proportion of many different compounds. Thus, many scientists have been drawn to the innovative capabilities of the MSI approach, leading to significant focus in various fields during the past few decades. This review describes the sampling protocol, working principle and applications of a few non-ambient and ambient ionization mass spectrometry imaging techniques. The non-ambient techniques include secondary ionization mass spectrometry and matrix-assisted laser desorption ionization, while the ambient techniques include desorption electrospray ionization, laser ablation electrospray ionization, probe electro-spray ionization, desorption atmospheric pressure photo-ionization and femtosecond laser desorption ionization. The review additionally addresses the advantages and disadvantages of ambient and non-ambient MSI techniques in relation to their suitability, particularly for biological samples used in tissue diagnostics. Last but not least, suggestions and conclusions are made regarding the challenges and future prospects of MSI.

质谱成像技术:非环境和环境电离方法。
利用一种称为质谱成像(MSI)的革命性分子成像技术,可以从样品表面实时获取分子信息。该技术可同时提供关于多种不同化合物的空间分布和相对比例的高空间分辨率信息。因此,许多科学家都被 MSI 方法的创新能力所吸引,在过去的几十年里,该技术在各个领域都得到了广泛关注。本综述介绍了一些非环境和环境电离质谱成像技术的取样方案、工作原理和应用。非环境技术包括二次电离质谱法和基质辅助激光解吸电离法,而环境技术包括解吸电喷雾电离法、激光烧蚀电喷雾电离法、探针电喷雾电离法、解吸大气压光电离法和飞秒激光解吸电离法。此外,综述还讨论了常温和非常温 MSI 技术在适用性方面的优缺点,特别是对组织诊断中使用的生物样本的适用性。最后,还就 MSI 面临的挑战和未来前景提出了建议和结论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
12.00
自引率
4.00%
发文量
137
审稿时长
6 months
期刊介绍: Critical Reviews in Analytical Chemistry continues to be a dependable resource for both the expert and the student by providing in-depth, scholarly, insightful reviews of important topics within the discipline of analytical chemistry and related measurement sciences. The journal exclusively publishes review articles that illuminate the underlying science, that evaluate the field''s status by putting recent developments into proper perspective and context, and that speculate on possible future developments. A limited number of articles are of a "tutorial" format written by experts for scientists seeking introduction or clarification in a new area. This journal serves as a forum for linking various underlying components in broad and interdisciplinary means, while maintaining balance between applied and fundamental research. Topics we are interested in receiving reviews on are the following: · chemical analysis; · instrumentation; · chemometrics; · analytical biochemistry; · medicinal analysis; · forensics; · environmental sciences; · applied physics; · and material science.
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