Systemic immune response of burns from the acute to chronic phase

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-06-18 DOI:10.1002/ams2.976

Akinori Osuka, Ayami Shigeno, Hiroshi Matsuura, Shinya Onishi, Kazuhiro Yoneda

引用次数: 0

Abstract

Immune responses that occur following burn injury comprise a series of reactions that are activated in response to damaged autologous tissues, followed by removal of damaged tissues and foreign pathogens such as invading bacteria, and tissue repair. These immune responses are considered to be programmed in living organisms. Developments of modern medicine have led to the saving of burned patients who could not be cured previously; however, the programmed response is no longer able to keep up, and various problems have arisen. This paper describes the mechanism of immune response specific to burn injury and the emerging concept of persistent inflammation, immunosuppression, and catabolism syndrome.

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烧伤从急性期到慢性期的全身免疫反应。

烧伤后出现的免疫反应包括一系列针对受损自体组织的激活反应，随后是清除受损组织和外来病原体（如入侵细菌）以及组织修复。这些免疫反应被认为是生物体内的程序性反应。现代医学的发展使以前无法治愈的烧伤病人得以挽救，但程序化反应已无法跟上，各种问题也随之出现。本文介绍了烧伤特有的免疫反应机制，以及新出现的持续炎症、免疫抑制和分解代谢综合征的概念。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.