Neuroendocrine Carcinoma of the Bladder: A Case Report

Pan Gao, Xinyu Li, Ziqiu He, Yifan Xu, Zhi Zhang
{"title":"Neuroendocrine Carcinoma of the Bladder: A Case Report","authors":"Pan Gao, Xinyu Li, Ziqiu He, Yifan Xu, Zhi Zhang","doi":"10.2147/rru.s470653","DOIUrl":null,"url":null,"abstract":": Primary bladder large cell neuroendocrine carcinoma (LCNEC) is a rare, aggressive neoplasm with high recurrence rates and poor prognosis. Traditional management has heavily relied on radical cystectomy, which, despite its aggressiveness, often results in unsatisfactory outcomes. Emerging evidence suggests the potential for less invasive, bladder-sparing approaches, yet detailed reports and long-term outcomes remain scarce. We report a groundbreaking case of a 59-year-old male diagnosed with primary bladder LCNEC, managed through a pioneering bladder-sparing multimodal treatment. This novel strategy included transurethral resection followed by a tailored chemoradiation protocol, resulting in exceptional disease control and preservation of bladder function over a 20-month follow-up period, without evidence of recurrence. This case underscores the viability of bladder conservation strategies as a legitimate alternative to radical cystectomy for managing LCNEC, presenting a beacon of hope for patients wishing to preserve bladder functionality. It prompts a reevaluation of traditional treatment paradigms and advocates for further research into multimodal, organ-sparing approaches for this challenging malignancy.","PeriodicalId":508497,"journal":{"name":"Research and Reports in Urology","volume":"20 24","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Research and Reports in Urology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2147/rru.s470653","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

: Primary bladder large cell neuroendocrine carcinoma (LCNEC) is a rare, aggressive neoplasm with high recurrence rates and poor prognosis. Traditional management has heavily relied on radical cystectomy, which, despite its aggressiveness, often results in unsatisfactory outcomes. Emerging evidence suggests the potential for less invasive, bladder-sparing approaches, yet detailed reports and long-term outcomes remain scarce. We report a groundbreaking case of a 59-year-old male diagnosed with primary bladder LCNEC, managed through a pioneering bladder-sparing multimodal treatment. This novel strategy included transurethral resection followed by a tailored chemoradiation protocol, resulting in exceptional disease control and preservation of bladder function over a 20-month follow-up period, without evidence of recurrence. This case underscores the viability of bladder conservation strategies as a legitimate alternative to radical cystectomy for managing LCNEC, presenting a beacon of hope for patients wishing to preserve bladder functionality. It prompts a reevaluation of traditional treatment paradigms and advocates for further research into multimodal, organ-sparing approaches for this challenging malignancy.
膀胱神经内分泌癌:病例报告
:原发性膀胱大细胞神经内分泌癌(LCNEC)是一种罕见的侵袭性肿瘤,复发率高、预后差。传统的治疗方法主要依赖根治性膀胱切除术,尽管这种方法具有侵袭性,但结果往往不尽人意。新的证据表明,微创、保留膀胱的方法具有潜力,但详细报告和长期疗效仍然很少。我们报告了一例开创性的病例,一名 59 岁的男性被诊断为原发性膀胱 LCNEC,通过开创性的保膀胱多模式治疗进行了处理。这种新颖的治疗策略包括经尿道切除术,然后是量身定制的化疗放疗方案,结果在 20 个月的随访期间,疾病得到了很好的控制,膀胱功能得到了很好的保护,而且没有复发的迹象。该病例强调了膀胱保护策略作为根治性膀胱切除术替代方法的可行性,为希望保留膀胱功能的患者带来了希望的灯塔。它促使人们重新评估传统的治疗模式,并提倡进一步研究多模式、保全器官的方法来治疗这种具有挑战性的恶性肿瘤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信