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Gefitinib Resensitization After a TKI-Free Interval in Osimertinib Resistant Non–Small-Cell Lung Cancer: A Glimpse of Hope in Time of Crisis?

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC
ACS Applied Electronic Materials Pub Date : 2024-06-10 DOI:10.1016/j.cllc.2024.06.003
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引用次数: 0

Abstract

  • •

    After osimertinib resistance some patients are still sensitive to EGFR blockage.

  • •

    Gefitinib rechallenge seems effective after a TKI-free interval.

  • •

    Liquid biopsy can track clonal evolution of EGFR mutated NSCLCs.

  • •

    Detection of EGFR mutations on ctDNA can identify patients for this strategy.

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奥希替尼耐药的非小细胞肺癌患者在无TKI间隔期后吉非替尼再敏感：危机时刻的一线希望？
-在奥希替尼耐药后，一些患者对表皮生长因子受体阻断仍然敏感。-在无TKI间隔期后，重新挑战吉非替尼似乎有效。-液体活检可追踪表皮生长因子受体突变的NSCLC的克隆演变。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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来源期刊
ACS Applied Electronic Materials
ACS Applied Electronic Materials Multiple-
CiteScore
7.20
自引率
4.30%
发文量
567
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