The incidence of severe complications in acanthamoeba keratitis: Qualitative and quantitative systematic assessment

IF 5.1 2区 医学 Q1 OPHTHALMOLOGY
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引用次数: 0

Abstract

Acanthamoeba keratitis (AK) is a rare, sight-threating corneal infection. The disease is challenging to diagnose and treat, and the amoeba can rapidly encyst, persisting in the tissue and causing recurrences. Medical therapy is conventionally considered the first line treatment, but advanced cases could require more invasive treatments like a “chaud” corneal transplant. We review the incidence of severe complications in patients affected by AK. Of 439 reports screened, 158 met our inclusion criteria. Incidence of severe complications was low, with 2.21 % patients developing perforation, 1 % requiring evisceration/enucleation and less than 1 % developing endophthalmitis. Corneal transplantation was required in 16.68 % of the cases. According to our results, and considering the reported incidences of these complications in other infectious keratitis, AK patients have an overall low risk of developing perforation, endophthalmitis, and enucleation/evisceration. Nevertheless, data available in the literature remain poor, and further randomized control trials are needed to confirm our findings.

棘阿米巴角膜炎严重并发症的发生率:定性和定量系统评估
阿卡阿米巴角膜炎(AK)是一种罕见的危及视力的角膜感染。这种疾病的诊断和治疗都很困难,阿米巴会迅速包囊,在组织中持续存在并导致复发。传统上,药物治疗被认为是第一线治疗方法,但晚期病例可能需要更多侵入性治疗,如 "chaud "角膜移植。我们回顾了 AK 患者严重并发症的发生率。在筛选出的 439 篇报告中,有 158 篇符合我们的纳入标准。严重并发症的发生率很低,2.21%的患者出现穿孔,1%的患者需要进行剥离/去核手术,不到1%的患者出现眼内炎。16.68%的病例需要角膜移植。根据我们的研究结果,并考虑到其他感染性角膜炎的并发症发生率,AK 患者发生穿孔、眼内炎和眼球摘除术的风险总体较低。尽管如此,文献中的数据仍然很少,需要进一步的随机对照试验来证实我们的研究结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Survey of ophthalmology
Survey of ophthalmology 医学-眼科学
CiteScore
10.30
自引率
2.00%
发文量
138
审稿时长
14.8 weeks
期刊介绍: Survey of Ophthalmology is a clinically oriented review journal designed to keep ophthalmologists up to date. Comprehensive major review articles, written by experts and stringently refereed, integrate the literature on subjects selected for their clinical importance. Survey also includes feature articles, section reviews, book reviews, and abstracts.
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