Functional connectivity of the posterior cingulate cortex in autism spectrum disorder

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Psychiatry Research: Neuroimaging Pub Date : 2024-06-13 DOI:10.1016/j.pscychresns.2024.111848

Myriam Kornisch , Claudia Gonzalez , Toshikazu Ikuta

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引用次数: 0

Abstract

The purpose of this study was to assess the functional connectivity of the posterior cingulate cortex in autism spectrum disorder (ASD). We used resting-state functional magnetic resonance imaging (rsfMRI) brain scans of adolescents diagnosed with ASD and a neurotypical control group. The Autism Brain Imaging Data Exchange (ABIDE) consortium was utilized to acquire data from the University of Michigan (145 subjects) and data from the New York University (183 subjects). The posterior cingulate cortex showed reduced connectivity with the anterior cingulate cortex for the ASD group compared to the control group. These two brain regions have previously both been linked to ASD symptomology. Specifically, the posterior cingulate cortex has been associated with behavioral control and executive functions, which appear to be responsible for the repetitive and restricted behaviors (RRB) in ASD. Our findings support previous data indicating a neurobiological basis of the disorder, and the specific functional connectivity changes involving the posterior cingulate cortex and anterior cingulate cortex may be a potential neurobiological biomarker for the observed RRBs in ASD.

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自闭症谱系障碍后扣带回皮层的功能连接性

本研究旨在评估自闭症谱系障碍（ASD）患者后扣带回皮层的功能连接性。我们使用静息态功能磁共振成像（rsfMRI）对被诊断患有自闭症谱系障碍的青少年和神经畸形对照组进行脑部扫描。我们利用自闭症大脑成像数据交换（ABIDE）联盟获取了密歇根大学（145 名受试者）的数据和纽约大学（183 名受试者）的数据。与对照组相比，ASD 患儿后扣带回皮层与前扣带回皮层的连接性降低。这两个脑区以前都与 ASD 症状有关。具体来说，后扣带回皮层与行为控制和执行功能有关，而行为控制和执行功能似乎是导致 ASD 重复和受限行为（RRB）的原因。我们的研究结果支持了以前的数据，这些数据表明了这种疾病的神经生物学基础，而涉及后扣带回皮层和前扣带回皮层的特定功能连接变化可能是在 ASD 中观察到的 RRB 的潜在神经生物学生物标记。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychiatry Research: Neuroimaging 医学-精神病学

CiteScore

3.80

自引率

0.00%

发文量

审稿时长

22.5 weeks

期刊介绍： The Neuroimaging section of Psychiatry Research publishes manuscripts on positron emission tomography, magnetic resonance imaging, computerized electroencephalographic topography, regional cerebral blood flow, computed tomography, magnetoencephalography, autoradiography, post-mortem regional analyses, and other imaging techniques. Reports concerning results in psychiatric disorders, dementias, and the effects of behaviorial tasks and pharmacological treatments are featured. We also invite manuscripts on the methods of obtaining images and computer processing of the images themselves. Selected case reports are also published.