Per oral endoscopic myotomy for achalasia

IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
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引用次数: 0

Abstract

Achalasia, characterized by impaired lower esophageal sphincter (LES) relaxation and failed peristalsis, stands out as the most widely recognized primary esophageal motility disorder. It manifests with dysphagia to solid and liquid foods, chest pain, regurgitation, and weight loss, leading to significant morbidity and healthcare burden. Traditionally, surgical Heller myotomy and pneumatic dilation were the primary therapeutic approaches for achalasia. However, in 2009, Inoue and colleagues introduced a groundbreaking endoscopic technique called peroral endoscopic myotomy (POEM), revolutionizing the management of this condition. This review aims to comprehensively examine the recent advancements in the POEM technique for patients diagnosed with achalasia, delving into critical aspects, such as the tailoring of the myotomy, the prevention of intraprocedural adverse events (AEs), the evaluation of long-term outcomes, and the feasibility of retreatment in cases of therapeutic failure.

治疗贲门失弛缓症的经口腔内窥镜肌切开术
以食管下括约肌(LES)松弛功能受损和蠕动功能障碍为特征的食管失弛缓症是公认的最常见的原发性食管运动障碍。它表现为吞咽固体和液体食物困难、胸痛、反流和体重减轻,导致严重的发病率和医疗负担。传统上,手术海勒肌切开术和气压扩张术是治疗贲门失弛缓症的主要方法。然而,2009 年,Inoue 及其同事推出了一种开创性的内窥镜技术--口周内窥镜肌切开术 (POEM),彻底改变了这种疾病的治疗方法。本综述旨在全面探讨针对贲门失弛缓症患者的口内镜肌切开术(POEM)的最新进展,深入探讨肌切开术的定制、术中不良事件(AEs)的预防、长期疗效评估以及治疗失败情况下再治疗的可行性等关键问题。
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来源期刊
CiteScore
5.50
自引率
0.00%
发文量
23
审稿时长
69 days
期刊介绍: Each topic-based issue of Best Practice & Research Clinical Gastroenterology will provide a comprehensive review of current clinical practice and thinking within the specialty of gastroenterology.
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