Powder agglomeration in continuous powder feeding by twin-screw feeder

IF 4.5 2区工程技术 Q2 ENGINEERING, CHEMICAL

Powder Technology Pub Date : 2024-06-15 DOI:10.1016/j.powtec.2024.120016

Zhanjie Liu , Fernando J. Muzzio , Gerardo Callegari

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Abstract

The presence of powder agglomerates results in product with poor content uniformity and intermittent high potency in the processing of pharmaceutical powders.

We developed a novel and easy-to-implement methodology, applying image analysis, to quantify the size of powder agglomerates when a powder passes through a screw feeder. Subsequently, agglomeration tendencies of twenty-one pharmaceutical powders were examined and classified. Notably, both the size and endurance of agglomerates were quantified, and our study revealed that the agglomeration tendency of powders can be explained by particle size and compressibility: Powders with small particle size (D50 < 30 μm), and large compressibility (> 35% at 15 kPa normal stress) tend to form large and enduring agglomerates, which can be difficult to eliminate in downstream processes. The study also illustrates how two materials, one that produces enduring and the other unenduring agglomerates, display substantially different content uniformity in the final product after being processed semi-continuously.

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双螺杆喂料机连续喂粉过程中的粉末团聚问题

在药粉加工过程中，粉末团聚的存在会导致产品的含量均匀性差，药效时高时低。我们开发了一种新颖且易于实施的方法，应用图像分析来量化粉末通过螺旋喂料机时粉末团聚的大小。随后，我们对 21 种药用粉末的结块趋势进行了检测和分类。值得注意的是，我们对团聚体的大小和耐久性都进行了量化，研究结果表明，粉末的团聚趋势可以用粒度和可压缩性来解释：粒度小（D50 < 30 μm）、可压缩性大（15 kPa 法向应力下为 35%）的粉末往往会形成大而持久的团聚体，这在下游工艺中很难消除。研究还说明了两种材料（一种会产生持久团聚体，另一种不会产生持久团聚体）在经过半连续加工后，在最终产品中显示出截然不同的含量均匀性。

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来源期刊

Powder Technology 工程技术-工程：化工

CiteScore

9.90

自引率

15.40%

发文量

1047

审稿时长

46 days

期刊介绍： Powder Technology is an International Journal on the Science and Technology of Wet and Dry Particulate Systems. Powder Technology publishes papers on all aspects of the formation of particles and their characterisation and on the study of systems containing particulate solids. No limitation is imposed on the size of the particles, which may range from nanometre scale, as in pigments or aerosols, to that of mined or quarried materials. The following list of topics is not intended to be comprehensive, but rather to indicate typical subjects which fall within the scope of the journal's interests: Formation and synthesis of particles by precipitation and other methods. Modification of particles by agglomeration, coating, comminution and attrition. Characterisation of the size, shape, surface area, pore structure and strength of particles and agglomerates (including the origins and effects of inter particle forces). Packing, failure, flow and permeability of assemblies of particles. Particle-particle interactions and suspension rheology. Handling and processing operations such as slurry flow, fluidization, pneumatic conveying. Interactions between particles and their environment, including delivery of particulate products to the body. Applications of particle technology in production of pharmaceuticals, chemicals, foods, pigments, structural, and functional materials and in environmental and energy related matters. For materials-oriented contributions we are looking for articles revealing the effect of particle/powder characteristics (size, morphology and composition, in that order) on material performance or functionality and, ideally, comparison to any industrial standard.

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