Brain tumor-associated epilepsies in adulthood: Current state of diagnostic and individual treatment options

IF 2.7 3区 医学 Q2 CLINICAL NEUROLOGY
Hermann Stefan , Frank Bösebeck , Karl Rössler
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引用次数: 0

Abstract

Brain tumors are one of the most frequent causes of structural epilepsy and set a major burden on treatment costs and the social integrity of patients. Although promising oncological treatment strategies are already available, epileptological treatment is often intractable and requires lifelong epileptological care. Therefore, treatment strategies must be adapted to age-related needs, and specific aspects of late-onset epilepsy (LOE) must be considered. The practical implementation of individual decisions from tumor boards and the current state of the art in scientific knowledge about pathological mechanisms, modern diagnostic procedures and biomarkers, and patient-individualized treatment options into practical epileptological disease management is a prerequisite.
This narrative review focuses on the current work progress regarding pathogenesis, diagnosis, and therapy. Exemplarily, interdisciplinary approaches for optimized individualized therapy will be discussed, emphasizing the combination of neurological-epileptological and oncological perspectives.
成年期脑肿瘤相关癫痫:诊断和个体治疗方案的现状。
脑肿瘤是结构性癫痫的最常见原因之一,对治疗费用和患者的社会诚信造成重大负担。虽然有希望的肿瘤治疗策略已经可用,但癫痫治疗往往是棘手的,需要终生的癫痫治疗。因此,治疗策略必须适应与年龄相关的需求,并且必须考虑晚发性癫痫(LOE)的具体方面。实际实施来自肿瘤委员会的个人决定,以及关于病理机制、现代诊断程序和生物标志物的科学知识的当前状态,以及患者个性化治疗方案进入实际的癫痫疾病管理是一个先决条件。本文就目前在发病机制、诊断和治疗方面的研究进展作一综述。例如,将讨论最优化个体化治疗的跨学科方法,强调神经-癫痫学和肿瘤学观点的结合。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Seizure-European Journal of Epilepsy
Seizure-European Journal of Epilepsy 医学-临床神经学
CiteScore
5.60
自引率
6.70%
发文量
231
审稿时长
34 days
期刊介绍: Seizure - European Journal of Epilepsy is an international journal owned by Epilepsy Action (the largest member led epilepsy organisation in the UK). It provides a forum for papers on all topics related to epilepsy and seizure disorders.
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