Light-induced antimicrobial activities of porphyrin derivatives as photosensitizers

IF 5.3 2区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

APL Materials Pub Date : 2024-06-01 DOI:10.1063/5.0213923

Shengman Yu, Jingwei Shi, Tingting Sun, Zhigang Xie, Liyuan Sun

引用次数: 0

Abstract

Antimicrobial photodynamic therapy has considerable promise in the fight against bacterial infections. The superior photophysical characteristics of porphyrins have made them effective photosensitizers in the field of phototherapy. Herein, the light-induced antimicrobial effects of three porphyrins with different substituents have been compared. 5,10,15,20-tetrakis(4-hydroxyphenyl) porphyrin (THPP) shows superior photosensitizing activity and antimicrobial ability under irradiation with green light. THPP can also inhibit and destroy mature Staphylococcus aureus biofilms under irradiation. This work provides a reference for the rational design of photosensitizers for application in antimicrobial photodynamic therapy.

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作为光敏剂的卟啉衍生物的光诱导抗菌活性

抗菌光动力疗法在抗击细菌感染方面大有可为。卟啉优越的光物理特性使其成为光疗领域有效的光敏剂。本文比较了三种具有不同取代基的卟啉的光诱导抗菌效果。5,10,15,20-四(4-羟基苯基)卟啉（THPP）在绿光照射下显示出卓越的光敏活性和抗菌能力。THPP 还能在照射下抑制和破坏成熟的金黄色葡萄球菌生物膜。这项工作为合理设计光敏剂应用于抗菌光动力疗法提供了参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

APL Materials NANOSCIENCE & NANOTECHNOLOGYMATERIALS SCIE-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

9.60

自引率

3.30%

发文量

199

审稿时长

2 months

期刊介绍： APL Materials features original, experimental research on significant topical issues within the field of materials science. In order to highlight research at the forefront of materials science, emphasis is given to the quality and timeliness of the work. The journal considers theory or calculation when the work is particularly timely and relevant to applications. In addition to regular articles, the journal also publishes Special Topics, which report on cutting-edge areas in materials science, such as Perovskite Solar Cells, 2D Materials, and Beyond Lithium Ion Batteries.

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