Colon Specific and Targeted Drug Delivery System (CDDS): A Review

Abstract

In the recent year colonic drug delivery is important for delivery of drug for the treatment of local disease. Targeted drug delivery into the colon is highly desirable for local treatment of a variety of bowel diseases such as ulcerative colitis, Crohn’s disease, amoebiosis, colonic cancer, local treatment of colonic pathologies, and systemic delivery of protein and peptide drugs. This article gives overview on different approaches of colon targeted drug delivery system such as pH sensitive polymer coated drug delivery to colon, time Controlled release drug delivery to Colon microbially triggered systems, prodrug approach to drug delivery to colon it also consist of recent approaches of colon targeted drug delivery such as pressure controlled drug-Delivery Systems, Novel Colon Targeted Delivery System (CODESTM), Osmotic Controlled Drug Delivery (ORDS-CT).