Phytochemicals as potential active principal components for formulation of alternative antifungal remedies against Trichophyton spp.: a systematic review

IF 2 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Pure and Applied Chemistry Pub Date : 2024-06-05 DOI:10.1515/pac-2023-1114

Rudo Zhou, P. Dzomba, L. Gwatidzo

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引用次数: 0

Abstract

Abstract In this age of emergent resistance to antimicrobial agents, pathogenic fungi are not an exception. Diverse strategies have been implemented to curb rampant fungal infections including screening new drugs and stewardship programs. A plethora of recent studies have proved that phytochemicals are efficacious against pathogenic fungi and have potent antifungal activity. This review examines the use of phytochemicals as possible alternative antifungal agents against dermatophytes particularly Trichophyton spp. Literature search was done using three search engines namely Google Scholar, PubMed and Science Direct limited to the year 2019–2023 only. A total of 30 articles were included and 48 plant extracts were evaluated. The major phytochemicals that proved to be potent antifungals both in vitro and in vivo were terpenoids and phenolics. The antifungal potential of phyto-compounds was significantly elevated by incarnation with nanotechnology. Although much has been done in screening of herbal extracts as possible antifungal agents huge gaps still exist on full characterization of all active herbal extracts with antifungal potential especially against resistant strains, together with their mechanism of action, formulation of pharmaceutical dosage forms and clinical trials.

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植物化学物质作为替代抗真菌药的潜在活性主要成分：系统综述

摘要在抗菌药耐药性不断涌现的今天，致病真菌也不例外。为遏制肆虐的真菌感染，人们实施了多种策略，包括筛选新药和管理计划。最近的大量研究证明，植物化学物质对病原真菌有效，并具有强大的抗真菌活性。本综述研究了植物化学物质作为可能的替代抗真菌剂对皮癣菌（尤其是毛癣菌属）的作用。文献检索使用了三个搜索引擎，即 Google Scholar、PubMed 和 Science Direct，仅限于 2019-2023 年。共收录了 30 篇文章，对 48 种植物提取物进行了评估。在体外和体内均被证明为有效抗真菌剂的主要植物化学物质是萜类化合物和酚类化合物。通过与纳米技术的结合，植物化合物的抗真菌潜力得到了显著提升。尽管在筛选草药提取物作为可能的抗真菌剂方面做了大量工作，但在全面描述所有具有抗真菌潜力（尤其是针对耐药菌株）的活性草药提取物的特征、作用机制、药物剂型的配制和临床试验方面仍存在巨大差距。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pure and Applied Chemistry 化学-化学综合

CiteScore

4.00

自引率

0.00%

发文量

审稿时长

3-8 weeks

期刊介绍： Pure and Applied Chemistry is the official monthly Journal of IUPAC, with responsibility for publishing works arising from those international scientific events and projects that are sponsored and undertaken by the Union. The policy is to publish highly topical and credible works at the forefront of all aspects of pure and applied chemistry, and the attendant goal is to promote widespread acceptance of the Journal as an authoritative and indispensable holding in academic and institutional libraries.