Clinical applications and perspectives of immune checkpoint inhibitors in oral squamous cell carcinoma

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-06-11 DOI:10.1515/oncologie-2024-0086

Liuyu Ru, Jiwei Zheng

引用次数: 0

Abstract

Abstract Immune checkpoint inhibitors (ICIs) promote antitumour immune responses by blocking inhibitory signals expressed by T cells and have significant clinical benefits in the treatment of oral squamous cell carcinoma (OSCC). With the advancement of immunotherapy, an increasing number of ICIs have been developed or are in clinical trial stages. However, drug resistance and immune-related adverse events (irAEs) associated with ICIs have limited the clinical application of immunotherapy in OSCC, and the optimal drug regimen for ICIs and the optimal duration of ICIs administration also deserves to be further discussed. New therapeutic regimens and drug delivery technologies are key to promoting the further development of ICIs. This article elucidates the mechanism of ICIs’ action and presents a review of their clinical applications and current development status in OSCC. Additionally, it summarizes the current challenges and outlines future research directions for ICIs therapy, with the aim of offering fresh insights to researchers.

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免疫检查点抑制剂在口腔鳞状细胞癌中的临床应用与展望

摘要免疫检查点抑制剂（ICIs）通过阻断T细胞表达的抑制信号来促进抗肿瘤免疫反应，在治疗口腔鳞状细胞癌（OSCC）方面具有显著的临床疗效。随着免疫疗法的发展，越来越多的 ICIs 已经研发成功或处于临床试验阶段。然而，与ICIs相关的耐药性和免疫相关不良事件（irAEs）限制了免疫疗法在OSCC中的临床应用，ICIs的最佳用药方案和ICIs的最佳用药时间也值得进一步探讨。新的治疗方案和给药技术是促进ICIs进一步发展的关键。本文阐明了 ICIs 的作用机制，回顾了 ICIs 在 OSCC 中的临床应用和发展现状。此外，文章还总结了ICIs疗法目前面临的挑战，并概述了未来的研究方向，旨在为研究人员提供新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.