Bringing nutritional ketosis to the table as an option for healing the pediatric brain

Tracy S. Gertler, Robyn Blackford
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Abstract

Our core premise is that personalized variations of a ketogenic diet are likely to benefit pediatric patients with neuropsychiatric symptoms across multiple domains. Although pediatric epilepsy is currently a well-accepted indication for a strict ketogenic diet, there is a dearth of knowledge and therefore clinical guidelines upon which to recommend nutritional ketosis for pervasive pediatric conditions such as autism spectrum disorder and ADHD, even when comorbid epilepsy is present. However, there are published cohort studies and current clinical trials implementing medical ketogenic therapies for cognitive impairment, psychiatric comorbidities, motor disability, and even neuroinflammation. As holistic practitioners, it is imperative that we consider the health of a child in its entirety - and additionally offer the ketogenic diet as a therapeutic option when it may be synergistic in treating extra-neurologic diseases such as obesity. While there are uniquely pediatric potential adverse side effects such as linear growth deceleration and micronutrient deficiencies, previous trials in epilepsy and our center’s experience have already proven the ketogenic diet to be a low-risk intervention when optimized with appropriate patient monitoring and support.
将营养酮病作为治疗小儿脑部疾病的一种选择
我们的核心前提是,个性化的生酮饮食很可能有益于有神经精神症状的儿科患者,而且涉及多个领域。虽然小儿癫痫是目前公认的严格生酮饮食的适应症,但对于自闭症谱系障碍和多动症等普遍存在的儿科疾病,即使合并有癫痫,也缺乏相关知识和临床指南来推荐营养性酮病。然而,有一些已发表的队列研究和当前的临床试验,对认知障碍、精神合并症、运动障碍甚至神经炎症实施了生酮医学疗法。作为全科医生,我们必须全面考虑儿童的健康状况,并在生酮饮食对治疗肥胖等神经系统外疾病具有协同作用时,将其作为一种治疗选择。虽然生酮饮食有其独特的儿科潜在不良副作用,如线性生长减速和微量营养素缺乏,但之前的癫痫试验和我们中心的经验已经证明,在适当的患者监测和支持下进行优化,生酮饮食是一种低风险的干预措施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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