The causal relationship between diet habits and cholelithiasis: a comprehensive Mendelian randomization (MR) study

Lin Xie, Mingzhi Xu, Yahan Lei, Juan Li, Jiajia Xie
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Abstract

Epidemiological studies show dietary habits can have an impact on the risk of cholelithiasis, but the relationship is still unclear. We used a comprehensive Mendelian randomization (MR) study to explore the relationship between dietary habits and cholelithiasis.The 18 dietary habits were divided into six categories: meat foods, cereals, vegetables, fruits, dairy products, beverages, and condiments. Cholelithiasis data came from a GWAS meta-analysis and the FinnGen consortium. The inverse variance weighted (IVW), the weighted median (WM), and MR-Egger approaches were used as the main MR analysis methods. In addition, multiple sensitivity analysis and meta-analysis were performed to verify the robustness of the results.Dried fruit intake [odds ratio (OR) = 0.568; 95% confidence interval (CI), 0.405–0.797; p = 0.001] was discovered to reduce the risk of cholelithiasis. The sensitivity analysis and meta-analysis showed reliable results for the relationship between dried fruit intake and cholelithiasis.Our study found that dried fruit intake is a protective factor in the development of cholelithiasis. However, the mechanisms of action need to be further explored.
饮食习惯与胆石症的因果关系:孟德尔随机化综合研究
流行病学研究表明,饮食习惯会对胆石症的发病风险产生影响,但两者之间的关系尚不明确。我们采用了一项综合性孟德尔随机化(MR)研究来探讨饮食习惯与胆石症之间的关系。18种饮食习惯分为六类:肉类食品、谷物、蔬菜、水果、乳制品、饮料和调味品。胆石症的数据来自 GWAS meta 分析和 FinnGen 财团。逆方差加权法(IVW)、加权中位数法(WM)和 MR-Egger 法是主要的 MR 分析方法。干果摄入量[几率比(OR)=0.568;95% 置信区间(CI),0.405-0.797;P = 0.001]被发现可降低胆石症的风险。敏感性分析和荟萃分析表明,干果摄入量与胆石症之间的关系结果可靠。我们的研究发现,干果摄入量是胆石症发病的保护因素,但其作用机制还有待进一步探讨。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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