Influence of Anthelmintic Treatment on Immune Response and Oxidative Stress in Cattle Vaccinated against Lumpy Skin Disease

Abstract

Background: Vaccination and deworming are routine programs in cattle health management. However, the anthelmintic’s effectiveness on the immune response in vaccinated cattle is limited. Therefore, this study investigated whether anthelmintic administration affects the oxidative stress and immunity induced by vaccination against lumpy skin disease (LSD) in cattle. Methods: Thirty-seven Thai beef cattle were divided into two groups. Group 1) 19 cattle were vaccinated against LSD with a Neethling LSD virus (LSDV) vaccine as the control group and Group 2) 18 cattle were vaccinated against LSD with a Neethling LSDV vaccine and received albendazole treatment. Then, the intensity of gastrointestinal parasite infestation, level of malondialdehyde, inflammatory cytokines and antibody titer to LSDV were investigated in both groups on day 30 of the experimental period. Result: The results showed that the types and intensity of gastrointestinal parasites were decreased in the anthelmintic-treated group. There were no significant differences in the levels of malondialdehyde, IFN-γ, TNF-α and LSD-specific antibody titers between the control and the anthelmintic treatment group (P greater than 0.05), while the expression level of IL-4 in the anthelmintic treatment group was significantly lower than in the control group (P less than 0.05). Our study indicated that albendazole treatment did not affect oxidative stress and innate and adaptive immunity against LSDV. Moreover, single-dose albendazole therapy led to a reduction in the expression level of IL-4, which is involved in defense against parasites.