Parthanatosis in virus-associated liver and colon cancer

Science and Innovations Pub Date : 2024-06-13 DOI:10.29235/1818-9857-2024-05-79-83

O. Kuznetsov, V. Tsirkunov

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Abstract

The biological marker of parthanatosis is Poly (ADP-ribose) polymerase (PARP), the activation of which is associated with various pathological processes in the body. Tumor tissue samples from patients with morphologically verified liver and colon cancer were studied. The control consisted of liver and intestinal tissues of the same patients not affected by a tumor, and intravital biopsies (native tissue) of the liver and intestines of non-cancer patients. Determination of the concentration of antibodies to PARP and determination of DNA/RNA viruses (VEB, HBV, HCV, HPV, CMV, HSV1/2, HHV6) in tissue samples was carried out by enzyme immunoassay and polymerase chain reaction method. The research results showed that the concentration of antibodies to PARP in tissue extracts from tumor processes is higher than in native tissue samples (p<0.05) and in tissue with «no criteria for malignancy» (p<0,05). The relationship between the frequency of isolation of DNA-containing viruses (HHV6, CMV, VEB) from tumor tissues and the concentration of PARP antibodies (p<0,05) suggests that DNA damage to cells is stimulated by viruses during oncogenesis of the liver and colon.

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病毒相关性肝癌和结肠癌中的副扁桃体病变

多聚（ADP-核糖）聚合酶（PARP）是副瘤病的生物标志物，它的活化与体内的各种病理过程有关。研究对象是经形态学验证的肝癌和结肠癌患者的肿瘤组织样本。对照组包括未受肿瘤影响的同一患者的肝脏和肠道组织，以及非癌症患者肝脏和肠道的活组织切片（原生组织）。组织样本中 PARP 抗体的浓度测定和 DNA/RNA 病毒（VEB、HBV、HCV、HPV、CMV、HSV1/2、HHV6）的测定采用酶免疫测定法和聚合酶链反应法进行。研究结果表明，肿瘤过程组织提取物中 PARP 抗体的浓度高于原生组织样本（P<0.05）和 "无恶性标准 "组织样本（P<0.05）。从肿瘤组织中分离出含DNA病毒（HHV6、CMV、VEB）的频率与PARP抗体浓度之间的关系（p<0.05）表明，在肝脏和结肠的肿瘤发生过程中，病毒会刺激细胞的DNA损伤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Science and Innovations

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