N,N-Dimethylformamide dimethyl acetal (DMFDMA): from derivatisation to C1 synthon

IF 1 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Australian Journal of Chemistry Pub Date : 2024-06-13 DOI:10.1071/ch24020

Natalie Ferreira Araujo, Sabrina Baptista Ferreira

引用次数: 0

Abstract

N,N-Dimethylformamide dimethyl acetal (DMFDMA), also called 1,1-dimethoxy-N,N-dimethylmethanamine, is a colorless liquid with rancid odour. The chemical structure of DMFDMA presents two important sites, a partially positive carbon that acts as an electrophile in condensation reactions and a partially negative nitrogen that acts as a nucleophile. Because of its structure, DMFDMA reacts with many different organic groups and can be a versatile reagent used in gas chromatography, as a protecting group and as a C1 synthon, especially in the construction of heterocycles.

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N,N-二甲基甲酰胺二甲基缩醛 (DMFDMA)：从衍生到 C1 合物

N,N-二甲基甲酰胺二甲基缩醛（DMFDMA）又称 1,1-二甲氧基-N,N-二甲基甲胺，是一种无色有酸臭味的液体。DMFDMA 的化学结构有两个重要部位，一个是在缩合反应中作为亲电子体的部分正碳，另一个是作为亲核体的部分负氮。由于其结构，DMFDMA 可与许多不同的有机基团发生反应，是一种用途广泛的试剂，可用于气相色谱法、作为保护基团和 C1 合剂，尤其是用于构建杂环。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Australian Journal of Chemistry 化学-化学综合

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

1.3 months

期刊介绍： Australian Journal of Chemistry - an International Journal for Chemical Science publishes research papers from all fields of chemical science. Papers that are multidisciplinary or address new or emerging areas of chemistry are particularly encouraged. Thus, the scope is dynamic. It includes (but is not limited to) synthesis, structure, new materials, macromolecules and polymers, supramolecular chemistry, analytical and environmental chemistry, natural products, biological and medicinal chemistry, nanotechnology, and surface chemistry. Australian Journal of Chemistry is published with the endorsement of the Commonwealth Scientific and Industrial Research Organisation (CSIRO) and the Australian Academy of Science.