Pharmaceutical Applications and Advances with Zetasizer: An Essential Analytical Tool for Size and Zeta Potential Analysis

Q3 Engineering

Micro and Nanosystems Pub Date : 2024-06-13 DOI:10.2174/0118764029301470240603051432

Sonakshi Garg, Preeti Patel, Ghanshyam Das Gupta, B. Kurmi

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引用次数: 0

Abstract

Zetasizer is an advanced device that measures various properties of particles or molecules suspended in a liquid medium. It is extensively used for evaluating the size of nanoparticles, colloids, and biomolecular particles, and for determining particle charge. There are several analytical techniques by which the size, zeta potential, and molecular weight can be determined, like Dynamic Light Scattering (DLS) that measures the size of particles in dispersed systems, which can range from sub-nanometers to several micrometers in diameter. Electrophoretic Light Scattering (ELS) analyzes the mobility and charge of particles, also known as the zeta potential. Static Light Scattering (SLS) determines the molecular weight of particles in a solution. The Zetasizer is part of the Zetasizer Advance range of benchtop systems available for laboratory use. The Zetasizer Ultra model offers unique measurement capabilities, such as Multi-angle Dynamic Light Scattering (MADLS) and particle concentration. These features offer a deeper understanding of samples, making the Zetasizer a vital instrument in numerous scientific and industrial applications. In this review, we have discussed Zetasizer’s principles for the determination of particle size, zeta potential, and molecular weight, along with its qualification and applications in different formulations.

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Zetasizer 的制药应用与进展：粒度和 Zeta 电位分析的基本分析工具

Zetasizer 是一种先进设备，用于测量悬浮在液体介质中的颗粒或分子的各种特性。它被广泛用于评估纳米颗粒、胶体和生物分子颗粒的大小以及确定颗粒电荷。有几种分析技术可用于确定粒度、ZETA 电位和分子量，如动态光散射（DLS）可测量分散体系中颗粒的粒度，其直径可从亚纳米到几微米不等。电泳光散射（ELS）分析颗粒的流动性和电荷，也称为 zeta 电位。静态光散射（SLS）测定溶液中颗粒的分子量。Zetasizer 是 Zetasizer Advance 系列实验室台式系统的一部分。Zetasizer Ultramodel 具有独特的测量功能，如多角度动态光散射（MADLS）和颗粒浓度。这些功能有助于更深入地了解样品，使 Zetasizer 成为众多科学和工业应用中的重要仪器。在这篇综述中，我们讨论了 Zetasizer 测定粒度、zeta 电位和分子量的原理，以及它在不同配方中的鉴定和应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Micro and Nanosystems Engineering-Building and Construction

CiteScore

1.60

自引率

0.00%

发文量