Disseminated Herpes Simplex Virus-1 in Previously Healthy Child Without Skin Rash

Abstract

Disseminated Herpes Simplex Virus (HSV) is a known fatal condition in neonate and immunocompromised patients. However, very few cases have been reported in immunocompetent host. We report a one year old child who was previously healthy, presented with febrile illness associated with decrease conscious level. Child has been found to have marked elevated liver enzymes. Ultimately diagnosed with disseminated. HSV (encephalitis/ hepatitis) based on Cerebrospinal fluid (CSF) polymerase chain reaction (PCR) finding of HSV as well as positive HSV Immunoglobulin M (IgM) serology. She received acyclovir course and follow up for 1 year showed excellent developmental outcome. Keywords: HSV, Encephalitis, Hepatitis.