Prognostic implications of mucosal and deep margin distances according to T-status in oral tongue squamous cell carcinoma: A single-center retrospective study.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-12-01 Epub Date: 2024-06-17 DOI:10.1002/hed.27844

Valentine Poissonnet, Bertille Segier, Raphaël Lopez, Aurore Siegfried, Agnès Dupret-Bories, Jérôme Sarini, Vinciane Poulet, Franck Delanoë, Sébastien Vergez, Emilien Chabrillac

{"title":"Prognostic implications of mucosal and deep margin distances according to T-status in oral tongue squamous cell carcinoma: A single-center retrospective study.","authors":"Valentine Poissonnet, Bertille Segier, Raphaël Lopez, Aurore Siegfried, Agnès Dupret-Bories, Jérôme Sarini, Vinciane Poulet, Franck Delanoë, Sébastien Vergez, Emilien Chabrillac","doi":"10.1002/hed.27844","DOIUrl":null,"url":null,"abstract":"Objective: To elucidate the prognostic implications of mucosal and deep margin distances in oral tongue squamous cell carcinoma (OTSCC), and to assess a different margin cut-off value in T1-T2 versus T3-T4 tumors.Methods: This single-center retrospective study included 223 patients who received surgery for a primary OTSCC between January 2017 and December 2021.Results: Multivariable analysis showed that deep margin distance ≥3 mm in T1-T2 tumors and ≥5 mm in T3-T4 tumors was significantly associated with better RFS and OS. Mucosal and deep margin distances were globally clinically useful for 2-year RFS prediction of T1-T2 tumors, for which deep margins seemed to have more clinical utility than mucosal margins. The influence of margin distances on 2-year RFS seemed greater for T1-T2 tumors than T3-T4 tumors.Conclusion: Mucosal and deep margin distances were associated with OS and RFS in OTSCC. Shorter deep margin distances may be aimed for in T1-T2 versus T3-T4 tumors.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/hed.27844","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/6/17 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: To elucidate the prognostic implications of mucosal and deep margin distances in oral tongue squamous cell carcinoma (OTSCC), and to assess a different margin cut-off value in T1-T2 versus T3-T4 tumors.

Methods: This single-center retrospective study included 223 patients who received surgery for a primary OTSCC between January 2017 and December 2021.

Results: Multivariable analysis showed that deep margin distance ≥3 mm in T1-T2 tumors and ≥5 mm in T3-T4 tumors was significantly associated with better RFS and OS. Mucosal and deep margin distances were globally clinically useful for 2-year RFS prediction of T1-T2 tumors, for which deep margins seemed to have more clinical utility than mucosal margins. The influence of margin distances on 2-year RFS seemed greater for T1-T2 tumors than T3-T4 tumors.

Conclusion: Mucosal and deep margin distances were associated with OS and RFS in OTSCC. Shorter deep margin distances may be aimed for in T1-T2 versus T3-T4 tumors.

查看原文本刊更多论文

根据口腔舌鳞状细胞癌的 T 状态确定粘膜和深缘距离对预后的影响：一项单中心回顾性研究。

目的阐明口腔舌鳞状细胞癌（OTSCC）黏膜和深部边缘距离对预后的影响，并评估T1-T2与T3-T4肿瘤的不同边缘截断值：这项单中心回顾性研究纳入了223名在2017年1月至2021年12月期间接受原发性OTSCC手术的患者：多变量分析显示，T1-T2肿瘤的深缘距离≥3 mm和T3-T4肿瘤的深缘距离≥5 mm与较好的RFS和OS显著相关。粘膜和深部边缘距离对预测T1-T2肿瘤的2年RFS具有全面的临床意义，其中深部边缘似乎比粘膜边缘更有临床意义。边缘距离对T1-T2肿瘤2年RFS的影响似乎大于T3-T4肿瘤：结论：粘膜边缘和深部边缘距离与OTSCC的OS和RFS有关。T1-T2肿瘤与T3-T4肿瘤相比，应尽量缩短深部边缘距离。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464