Association of angiotensin-converting enzyme gene variations with coronary artery disease in the Iranian population.

IF 0.5 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

ARYA Atherosclerosis Pub Date : 2023-01-01 DOI:10.48305/arya.2022.11869.2692

Ayda Ghaffarzadeh, Mohadeseh Nemati, Mahsa Hassan-Nejhad, Kamal Khadem-Vatani, Sahar Baghal-Sadriforoush, Morteza Bagheri

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引用次数: 0

Abstract

Background: The purpose of this study was to identify the angiotensin-converting enzyme (ACE) gene (I/D) variations in CAD patients and healthy controls in an Iranian population (West Azerbaijan province of Iran).

Method: This cross-sectional study included 95 CAD patients and 203 healthy controls. ACE I/D polymorphisms were assessed using PCR, and their frequency was determined.

Results: There were 298 people, 95 CAD patients, and 203 controls, with an average age of 50.96±3.45 and 51.14±10.20. We discovered that the frequency of the D allele was significantly higher in CAD patients than in controls (P = 0.0009). In contrast, the frequency of the I allele was significantly higher in controls than in CAD patients (P = 0.0009). The D allele carriers genotypes (DD + ID) were more frequent in the CAD patients than in the control group (P = 0.008). The ACE II genotype-state carriers were more common in the control group than in CAD patients (P = 0.008). However, in the case of the ACE ID genotype, no significant differences were not found in the tested groups (P = 0.47).

Conclusions: These findings suggest that individuals with the ACE DD genotype are predisposed to CAD, whereas individuals with the ACE II genotype state are protected.

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伊朗人群中血管紧张素转换酶基因变异与冠心病的关系。

背景：本研究的目的是确定伊朗人群（伊朗西阿塞拜疆省）中 CAD 患者和健康对照者的血管紧张素转换酶（ACE）基因（I/D）变异：这项横断面研究包括 95 名 CAD 患者和 203 名健康对照者。方法：这项横断面研究包括 95 名 CAD 患者和 203 名健康对照者，采用 PCR 方法评估 ACE I/D 多态性，并确定其频率：结果：298 人中，95 人为 CAD 患者，203 人为对照组，平均年龄（50.96±3.45）岁和（51.14±10.20）岁。我们发现，D 等位基因在 CAD 患者中的频率明显高于对照组（P = 0.0009）。相反，I 等位基因在对照组中的频率明显高于 CAD 患者（P = 0.0009）。D 等位基因携带者基因型（DD + ID）在 CAD 患者中的出现频率高于对照组（P = 0.008）。ACE II 基因型携带者在对照组中比在 CAD 患者中更常见（P = 0.008）。然而，在 ACE ID 基因型的情况下，测试组没有发现显著差异（P = 0.47）：这些研究结果表明，具有 ACE DD 基因型的人易患 CAD，而具有 ACE II 基因型的人则受到保护。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ARYA Atherosclerosis CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

1.00

自引率

0.00%

发文量

审稿时长

18 weeks