Altered lymphocyte profiles and herpes zoster infections in patients with multiple sclerosis on natalizumab.

IF 4.8 2区医学 Q1 CLINICAL NEUROLOGY

Multiple Sclerosis Journal Pub Date : 2024-09-01 Epub Date: 2024-06-16 DOI:10.1177/13524585241260537

Alexandra Balshi, Nova Manning, John Dempsey, Sachin Kumbar, Ursela Baber, Jacob A Sloane

引用次数: 0

Abstract

Cases of herpes zoster (HZ) in patients with MS on natalizumab (NTZ) have been documented. In this study, we assessed lymphocyte subsets in NTZ-treated patients with HZ compared to matched controls without HZ. Twenty unvaccinated patients developed HZ while on NTZ for an incidence rate of 12.3 per 1000 patient-years. These patients had lower CD8+% and higher CD4+:CD8+ ratios (p ⩽ 0.01) than non-HZ matched controls. Two patients with relapsing-remitting MS developed HZ twice while on NTZ. These findings underscore the importance of pre-NTZ HZ vaccination due to potential HZ risk.

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使用纳他珠单抗的多发性硬化症患者的淋巴细胞谱改变和带状疱疹感染。

接受纳他珠单抗（NTZ）治疗的多发性硬化症患者出现带状疱疹（HZ）的病例已有记录。在这项研究中，我们评估了接受过 NTZ 治疗的 HZ 患者的淋巴细胞亚群，并与未患 HZ 的匹配对照组进行了比较。20名未接种疫苗的患者在服用NTZ期间患上了HZ，发病率为每1000患者年12.3例。这些患者的 CD8+% 和 CD4+:CD8+ 比率（p ⩽ 0.01）均低于非 HZ 匹配对照组（p ⩽ 0.01）。两名复发缓解型多发性硬化症患者在服用 NTZ 期间两次出现 HZ。这些发现强调了由于潜在的 HZ 风险而在服用 NTZ 前接种 HZ 疫苗的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Multiple Sclerosis Journal 医学-临床神经学

CiteScore

10.90

自引率

6.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Multiple Sclerosis Journal is a peer-reviewed international journal that focuses on all aspects of multiple sclerosis, neuromyelitis optica and other related autoimmune diseases of the central nervous system. The journal for your research in the following areas: * __Biologic basis:__ pathology, myelin biology, pathophysiology of the blood/brain barrier, axo-glial pathobiology, remyelination, virology and microbiome, immunology, proteomics * __Epidemology and genetics:__ genetics epigenetics, epidemiology * __Clinical and Neuroimaging:__ clinical neurology, biomarkers, neuroimaging and clinical outcome measures * __Therapeutics and rehabilitation:__ therapeutics, rehabilitation, psychology, neuroplasticity, neuroprotection, and systematic management Print ISSN: 1352-4585