Comprehensive Overview of Candida auris: An Emerging Multidrug-Resistant Fungal Pathogen.

IF 2.5 4区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Journal of microbiology and biotechnology Pub Date : 2024-07-28 Epub Date: 2024-06-15 DOI:10.4014/jmb.2404.04040

Ji-Seok Kim, Hyunjin Cha, Yong-Sun Bahn

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引用次数: 0

Abstract

The rise of Candida auris, a multidrug-resistant fungal pathogen, across more than 40 countries, has signaled an alarming threat to global health due to its significant resistance to existing antifungal therapies. Characterized by its rapid spread and robust drug resistance, C. auris presents a critical challenge in managing infections, particularly in healthcare settings. With research on its biological traits and genetic basis of virulence and resistance still in the early stages, there is a pressing need for a concerted effort to understand and counteract this pathogen. This review synthesizes current knowledge on the epidemiology, biology, genetic manipulation, pathogenicity, diagnostics, and resistance mechanisms of C. auris, and discusses future directions in research and therapeutic development. By exploring the complexities surrounding C. auris, we aim to underscore the importance of advancing research to devise effective control and treatment strategies.

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全面概述白色念珠菌：一种新出现的耐多药真菌病原体。

由于对现有抗真菌疗法产生严重耐药性，耐多药真菌病原体白色念珠菌在 40 多个国家中的崛起对全球健康构成了令人担忧的威胁。这种真菌具有传播迅速和耐药性强的特点，给管理感染，尤其是医疗机构的感染带来了严峻的挑战。由于对其生物特性以及毒力和耐药性遗传基础的研究仍处于早期阶段，因此迫切需要各方共同努力来了解和应对这种病原体。这篇综述综合了目前关于 C. auris 的流行病学、生物学、基因操作、致病性、诊断和抗药性机制的知识，并讨论了未来的研究和治疗开发方向。通过探讨 C. auris 的复杂性，我们旨在强调推进研究以制定有效控制和治疗策略的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of microbiology and biotechnology BIOTECHNOLOGY & APPLIED MICROBIOLOGY-MICROBIOLOGY

CiteScore

5.50

自引率

3.60%

发文量

151

审稿时长

2 months

期刊介绍： The Journal of Microbiology and Biotechnology (JMB) is a monthly international journal devoted to the advancement and dissemination of scientific knowledge pertaining to microbiology, biotechnology, and related academic disciplines. It covers various scientific and technological aspects of Molecular and Cellular Microbiology, Environmental Microbiology and Biotechnology, Food Biotechnology, and Biotechnology and Bioengineering (subcategories are listed below). Launched in March 1991, the JMB is published by the Korean Society for Microbiology and Biotechnology (KMB) and distributed worldwide.